INT251975

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 8.98
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lateral 2
neuronal 1
neutrophils 1
Pkhd1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 24 92.60 High High
cytokine 36 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
chemokine 28 5.00 Very Low Very Low Very Low
insula 22 5.00 Very Low Very Low Very Low
adenocard 16 5.00 Very Low Very Low Very Low
Anterior cingulate cortex 14 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
Transcranial magnetic stimulation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 436 100.00 Very High Very High Very High
Status Epilepticus 424 99.98 Very High Very High Very High
Urological Neuroanatomy 56 99.48 Very High Very High Very High
Death 56 96.96 Very High Very High Very High
Nicotine Addiction 28 88.76 High High
Cancer 50 84.72 Quite High
Cognitive Disorder 14 84.24 Quite High
Disease 16 60.92 Quite High
Syndrome 12 59.12 Quite High
INFLAMMATION 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the FPC kindreds, the hazard of pancreatic cancer increased as the age of the youngest proband decreased (HR = 1.55 per year of decreased age of the proband, 95% CI = 1.19 to 2.03).
Positive_regulation (increased) of FPC associated with pancreatic cancer
1) Confidence 0.10 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2808346 Disease Relevance 1.71 Pain Relevance 0
Risk of pancreatic cancer was elevated in both FPC kindred members (SIR = 6.79, 95% confidence interval [CI] = 4.54 to 9.75, P < .001) and sporadic pancreatic cancer (SPC) kindred members (SIR = 2.41, 95% CI = 1.04 to 4.74, P = .04) compared with the general population.
Positive_regulation (elevated) of FPC associated with pancreatic cancer
2) Confidence 0.09 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Abstract Doc Link PMC2808346 Disease Relevance 1.77 Pain Relevance 0
Two-to-three days after SE, the number of MPO-positive neutrophils was increased in the FPC (Figure 2C2-3).
Positive_regulation (increased) of FPC in neutrophils associated with status epilepticus and urological neuroanatomy
3) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.86 Pain Relevance 0
Three-to-four days after SE, the number of CD68-positive cells had significantly increased in the FPC (Figures 6B2-3 and 6D).
Positive_regulation (increased) of FPC associated with status epilepticus
4) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.98 Pain Relevance 0.06
Three-to-four days after SE, the number of CD68 positive cells had significantly increased in the FPC (Figures 4A2-3 and 4D).
Positive_regulation (increased) of FPC associated with status epilepticus
5) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.27 Pain Relevance 0
Furthermore, IL-1Ra infusion did not attenuate SE-induced neuronal damages in the FPC, compared to saline-infused animals (data not shown).
Neg (not) Positive_regulation (induced) of FPC in neuronal associated with status epilepticus
6) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.11 Pain Relevance 0.09
Mentalizing was more likely to be associated with activation in the caudal medial FPC, whereas activation in the lateral FPC supports high-level guidance of task performance over extended periods of time (Christoff & Gabrieli 2000).
Positive_regulation (activation) of FPC in lateral
7) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581786 Disease Relevance 0.14 Pain Relevance 0
Mentalizing was more likely to be associated with activation in the caudal medial FPC, whereas activation in the lateral FPC supports high-level guidance of task performance over extended periods of time (Christoff & Gabrieli 2000).
Positive_regulation (activation) of FPC in lateral
8) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581786 Disease Relevance 0.14 Pain Relevance 0

General Comments

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