INT251976

Context Info Confidence 0.52 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.95 Pain Relevance 0.07

signal transduction (TLE1) nucleus (TLE1) transcription factor binding (TLE1)

Anatomy Link Frequency node 1 TLE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Cannabinoid 37 83.64 COX-2 inhibitor 13 60.80 Glutamate 26 5.00 agonist 25 5.00 antagonist 12 5.00 insula 11 5.00 Anterior cingulate cortex 7 5.00 cINOD 7 5.00 Action potential 7 5.00 Hippocampus 5 5.00

Disease Link Frequency Relevance Heat Epilepsy 51 100.00 Convulsion 34 99.30 Gliosis 2 91.08 Colon Cancer 26 83.64 Stress 2 64.44 Hypoxia 1 64.16 Cancer 8 50.04 Neurological Disease 1 27.52 Status Epilepticus 37 5.00 Cognitive Disorder 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The upregulation of WIF1, SMAD4 and TLE1 would be expected to counteract ?

Positive_regulation (upregulation) of TLE1

1) Confidence 0.52 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.32 Pain Relevance 0.03

For example, in the ESG, the choice of the branch labelled R (reject) by player 1 and the branch labelled A (accept) by player 2 results in the terminal node t4 and the pay-offs U1(t4)=8 and U2(t4)=2.

Positive_regulation (results) of ESG in node

2) Confidence 0.14 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581786 Disease Relevance 0 Pain Relevance 0

These changes occur variably in concert with the development of spontaneous recurrent seizures in humans and in animal models of inducible TLE.

Positive_regulation (inducible) of TLE associated with epilepsy and convulsion

3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.62 Pain Relevance 0.04

General Comments

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