INT25198

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Context Info
Confidence 0.27
First Reported 1989
Last Reported 1989
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pkia) cytoplasm (Pkia)
Anatomy Link Frequency
brain 2
locus coeruleus 1
Pkia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 18 100.00 Very High Very High Very High
Locus ceruleus 16 99.76 Very High Very High Very High
Morphine 17 99.56 Very High Very High Very High
Dextromethorphan 2 97.76 Very High Very High Very High
antidepressant 5 97.32 Very High Very High Very High
tolerance 10 97.08 Very High Very High Very High
addiction 10 96.52 Very High Very High Very High
Raphe 2 79.28 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 86.76 High High
Convulsion 1 82.36 Quite High
Urological Neuroanatomy 4 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect appears to be specific to antidepressant drugs, because representatives of several other classes of psychotropic drugs-namely, haloperidol, morphine, and diazepam--failed to alter either soluble or particulate levels of cyclic AMP-dependent protein kinase activity in this brain region following chronic administration.
Neg (failed) Regulation (alter) of cyclic AMP-dependent protein kinase in brain associated with antidepressant and morphine
1) Confidence 0.27 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2795022 Disease Relevance 0.24 Pain Relevance 0.29
Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.
Regulation (Regulation) of cyclic AMP-dependent protein kinase in locus coeruleus associated with locus ceruleus and clonidine
2) Confidence 0.24 Published 1989 Journal Life Sci. Section Title Doc Link 2507846 Disease Relevance 0.15 Pain Relevance 1.35
Chronic administration of a number of other drugs, namely diazepam, chloral hydrate, and dextromethorphan, which produce electrophysiological actions distinct from those of clonidine and morphine in the LC, failed to alter adenylate cyclase and cyclic AMP-dependent protein kinase in this brain region.
Neg (failed) Regulation (alter) of cyclic AMP-dependent protein kinase in brain associated with locus ceruleus, dextromethorphan, morphine and clonidine
3) Confidence 0.24 Published 1989 Journal Life Sci. Section Abstract Doc Link 2507846 Disease Relevance 0.13 Pain Relevance 1.68

General Comments

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