INT2520

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 10
Speculated 1
Reported most in Abstract
Documents 271
Total Number 272
Disease Relevance 72.13
Pain Relevance 83.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
astrocyte 11
plasma 9
external 8
neurons 6
heart 5
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 1365 100.00 Very High Very High Very High
nMDA receptor 254 100.00 Very High Very High Very High
Hippocampus 150 100.00 Very High Very High Very High
Calcium channel 99 100.00 Very High Very High Very High
nociceptor 37 100.00 Very High Very High Very High
Enkephalin 35 100.00 Very High Very High Very High
Morphine 43 99.98 Very High Very High Very High
Clonidine 29 99.98 Very High Very High Very High
agonist 583 99.96 Very High Very High Very High
Hyperalgesia 46 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 3551 100.00 Very High Very High Very High
Brain Injury 58 100.00 Very High Very High Very High
Repression 3 100.00 Very High Very High Very High
Ocular Hypertension 415 99.92 Very High Very High Very High
Hyperalgesia 59 99.90 Very High Very High Very High
Blister 3 99.84 Very High Very High Very High
Apoptosis 143 99.82 Very High Very High Very High
Myocardial Infarction 131 99.82 Very High Very High Very High
Endotoxemia 110 99.82 Very High Very High Very High
Stress 455 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of mast cells with lidocaine, an inhibitor of Ca2+ binding to phospholipid, or with nordihydroguaiaretic acid, an inhibitor of Ca2+ flux and lipoxygenase, stimulated arachidonic acid-induced histamine release.
Negative_regulation (inhibitor) of Ca2 in mast cells associated with lidocaine
1) Confidence 0.57 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6203535 Disease Relevance 0 Pain Relevance 0.10
Dantrolene decreases the release of calcium from intracellular stores and thapsigargin is able to inhibit the reticular Ca2+-ATPase, avoiding intracellular calcium storage.
Negative_regulation (inhibit) of Ca2
2) Confidence 0.57 Published 2001 Journal Pharmacology Section Abstract Doc Link 11287815 Disease Relevance 0.17 Pain Relevance 0.32
In addition, an increase in axonal excitability of C fibres was seen during a rise in [Ca2+]i induced by inhibition of the endoplasmic Ca2 ATPase with cyclopiazonic acid.
Negative_regulation (inhibition) of Ca2 associated with c fibre
3) Confidence 0.57 Published 2001 Journal Pain Section Abstract Doc Link 11376907 Disease Relevance 0.11 Pain Relevance 0.50
In contrast, KB-R 7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate; 1 and 3 microM), a highly potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX1), failed to inhibit the K+- and veratridine-induced increase in [Ca2+]i.
Negative_regulation (inhibitor) of Ca2
4) Confidence 0.56 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9453466 Disease Relevance 0 Pain Relevance 0.11
The [Ca2+]i response to anoxia was therefore measured under control conditions and following depletion of specific Ca2+ stores.
Negative_regulation (depletion) of Ca2 associated with hypoxia
5) Confidence 0.50 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.51 Pain Relevance 0
These data indicate that anoxia causes a slow depletion of ER Ca2+ store content.
Negative_regulation (depletion) of Ca2 associated with hypoxia
6) Confidence 0.50 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.76 Pain Relevance 0
However, the Ca2+ transients triggered by comparable LCC currents are decreased in amplitude and/or slowed in kinetics in most models of decompensated hypertrophy (DHT) and heart failure [11,13].
Negative_regulation (decreased) of Ca2 in heart associated with hypertrophy and myocardial infarction
7) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 1.12 Pain Relevance 0
The speed of rise and average Ca2+ amplitude were generally unaffected by removal of Ca2+, with the exception of a slight decrease of the Ca2+ concentration reached when ATP was used (data not shown).
Negative_regulation (removal) of Ca2
8) Confidence 0.47 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.06 Pain Relevance 0
This is one of the first indications of the involvement of mitochondria in the control of cytoplasmic Ca2+ changes in microglia, and further investigation is needed to come to an unambiguous interpretation of this result since FCCP can have a number of outcomes together with the decrease of Ca2+ uptake by mitochondria, such as ATP depletion and pH changes.
Negative_regulation (decrease) of Ca2 in microglia
9) Confidence 0.47 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.03
The speed of rise and average Ca2+ amplitude were generally unaffected by removal of Ca2+, with the exception of a slight decrease of the Ca2+ concentration reached when ATP was used (data not shown).
Negative_regulation (decrease) of Ca2
10) Confidence 0.47 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.07 Pain Relevance 0
This result strongly suggests that the decrease in HR by U50488H is modulated by both OR activation and Ca2+ channel inhibition.
Negative_regulation (inhibition) of Ca2 associated with opioid receptor
11) Confidence 0.44 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872865 Disease Relevance 0.25 Pain Relevance 0.18
Neither tetrodotoxin, a combination of ionotropic and metabotropic glutamate receptor antagonists (D-amino-phosphonovalerate, 6-cyano-7-nitroquinoxaline-2,3-dione plus S-methyl-4-carboxyphenylglycine) nor bepridil, an inhibitor of the Na+/Ca2+-exchanger, affected these responses to O2/ glucose.
Negative_regulation (inhibitor) of Ca2 associated with tetrodotoxin, antagonist and glutamate receptor
12) Confidence 0.42 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824470 Disease Relevance 0.08 Pain Relevance 0.27
These results indicate that KB-R7943, a selective Na+/Ca2+ exchange inhibitor, has beneficial effects against myocardial ischemia/reperfusion injury and suggest that activation of the Na+/Ca2+ exchange mainly occurs immediately after reperfusion in the pathophysiological process of myocardial ischemia/reperfusion injury.
Negative_regulation (inhibitor) of Ca2 associated with reperfusion injury, coronary artery disease and ischemia
13) Confidence 0.42 Published 1998 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 9558649 Disease Relevance 0.90 Pain Relevance 0.41
The Ca2+-dependent ATPase is more selectively inhibited at lower drug concentrations.
Negative_regulation (inhibited) of Ca2
14) Confidence 0.41 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2942639 Disease Relevance 0.09 Pain Relevance 0.37
Blockade of the Na+/K+ ATPase by ouabain and of the Ca2+ ATPase by vanadate caused a net increase in cellular 45Ca2+ accumulation.
Negative_regulation (Blockade) of Ca2
15) Confidence 0.41 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2411261 Disease Relevance 0 Pain Relevance 0.23
Blockage of the Ca2+-ATPase pump, which inhibits the extrusion of calcium, plays a significant role in the process and enhances CIC.
Negative_regulation (Blockage) of Ca2
16) Confidence 0.41 Published 2001 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11903504 Disease Relevance 0 Pain Relevance 0.24
Surprisingly, endogenous release of NO elicited by glutamate was accompanied by vasoconstriction that was abolished by inhibition of Ca2+-phopholipase A2 and impaired by cyclooxygenase and thromboxane synthase inhibition and endothelin A receptor blockade, indicating a role for prostanoids and endothelin 1 in this response.
Negative_regulation (inhibition) of Ca2 associated with glutamate and increased venous pressure under development
17) Confidence 0.41 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16807329 Disease Relevance 0.48 Pain Relevance 0.19
Chronic inhibition of intracellular Ca2+ release or protein kinase C activation significantly reduces the development of morphine dependence.
Negative_regulation (inhibition) of Ca2 associated with addiction, kinase c and morphine
18) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8739205 Disease Relevance 0.26 Pain Relevance 0.74
Both phenylephrine and clonidine inhibited Ca2+/Mg2+-ATPase, in a concentration-dependent fashion.
Negative_regulation (inhibited) of Ca2 associated with clonidine
19) Confidence 0.41 Published 1987 Journal Neurochem. Res. Section Abstract Doc Link 2890113 Disease Relevance 0 Pain Relevance 0.43
This loss of protein thiols may have been responsible for the observed inhibition of the high-affinity Ca2+-ATPase activity of the plasma membrane fraction isolated from NAPQI-treated cells.
Negative_regulation (inhibition) of Ca2 in plasma
20) Confidence 0.39 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2932433 Disease Relevance 0.24 Pain Relevance 0.21

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