INT25208

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 43
Total Number 45
Disease Relevance 30.64
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
Anatomy Link Frequency
stromal cell 2
fibroblast 1
epithelial cell 1
dopamine neurons 1
fat 1
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 100.00 Very High Very High Very High
Dopamine 581 99.28 Very High Very High Very High
Clonidine 2 96.16 Very High Very High Very High
Angina 1 94.48 High High
palliative 20 91.56 High High
midbrain 140 88.56 High High
Bile 6 87.32 High High
cINOD 1 80.88 Quite High
Chronic pancreatitis 13 79.28 Quite High
antagonist 15 76.16 Quite High
Disease Link Frequency Relevance Heat
Stress 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Syndrome 127 99.88 Very High Very High Very High
Malignant Neoplastic Disease 67 99.68 Very High Very High Very High
Endometrial Cancer 153 99.64 Very High Very High Very High
Gastrointestinal Stromal Tumor 216 99.60 Very High Very High Very High
Benign Prostatic Hypertrophy 115 99.56 Very High Very High Very High
Disease 178 99.54 Very High Very High Very High
Cancer 824 99.46 Very High Very High Very High
Prostate Cancer 45 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Searching via MEDLINE, PubMed, Gold Rush and article cross-referencing, we only found 4 other publications of NICTH in GIST; four of which had overexpression of "big" IGF II and in two there was overexpression of pro-IGF II [9-12].
Gene_expression (overexpression) of IGF II associated with gastrointestinal stromal tumor
1) Confidence 0.74 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.89 Pain Relevance 0
Tumor analysis confirmed excessive production of insulin-like growth factor II m-RNA and the precursor protein, "big" insulin-like growth factor II.
Gene_expression (production) of insulin-like growth factor II associated with cancer
2) Confidence 0.74 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1781460 Disease Relevance 1.62 Pain Relevance 0.07
Tumor analysis confirmed excessive production of insulin-like growth factor II m-RNA and the precursor protein, "big" insulin-like growth factor II.
Gene_expression (production) of insulin-like growth factor II associated with cancer
3) Confidence 0.74 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1781460 Disease Relevance 1.60 Pain Relevance 0.06
Searching via MEDLINE, PubMed, Gold Rush and article cross-referencing, we only found 4 other publications of NICTH in GIST; four of which had overexpression of "big" IGF II and in two there was overexpression of pro-IGF II [9-12].
Gene_expression (overexpression) of pro-IGF II associated with gastrointestinal stromal tumor
4) Confidence 0.65 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.84 Pain Relevance 0
Consequently, Hizuka et al. demonstrated that IGF I was always low in hypoglycemic patients with "big" IGF II, while those without elevated "big" IGF II had both low IGF I and II [27].
Gene_expression (had) of IGF II
5) Confidence 0.65 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.67 Pain Relevance 0
These cells produced insulin-like growth factor type II mRNA as demonstrated by non-isotopic in situ hybridization.
Gene_expression (produced) of insulin-like growth factor type II mRNA
6) Confidence 0.54 Published 2001 Journal Eur. Urol. Section Abstract Doc Link 11306891 Disease Relevance 0.65 Pain Relevance 0.15
While the expression of IGF-2 was slightly different between tumor grades, this was not statistical significant (P = 0.093; Figure 1).
Gene_expression (expression) of IGF-2 associated with cancer
7) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.59 Pain Relevance 0
A score of 0-5 was considered negative (IGF2BP3 and IGF-2 not overexpressed), and a score of 6 and higher was considered positive (overexpression of IGF2BP3 and IGF-2) in accordance with Koebel et al. [21].
Gene_expression (overexpression) of IGF-2
8) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.30 Pain Relevance 0
A score of 0-5 was considered negative (IGF2BP3 and IGF-2 not overexpressed), and a score of 6 and higher was considered positive (overexpression of IGF2BP3 and IGF-2) in accordance with Koebel et al. [21].
Neg (not) Gene_expression (overexpressed) of IGF-2
9) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.31 Pain Relevance 0
We also demonstrated that the expression of IGF-2 significantly correlates with that of IGF2BP3, which has been previously reported to promote IGF-2 mRNA translation [2].
Gene_expression (expression) of IGF-2
10) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.97 Pain Relevance 0
However, the staining within benign tissue was exclusively located in acinar cells and, like IGF2BP3, absent in ductal cells, implying IGF2BP3-independent regulation of IGF-2 expression in the acinar cells.
Gene_expression (expression) of IGF-2 in acinar cells
11) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.38 Pain Relevance 0
Corcoran et al. [29] recently noted that induction of IGF-2 expression in pre-malignant lesions coincides with progression to advanced medulloblastoma.
Gene_expression (expression) of IGF-2 associated with malignant neoplastic disease and medulloblastoma
12) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 1.40 Pain Relevance 0.04
Calculations for disease specific survival for IGF-2 expression alone did not show any difference between the cohorts (data not shown).


Gene_expression (expression) of IGF-2 associated with disease
13) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.85 Pain Relevance 0
IGF-2, in comparison to IGF2BP3, was expressed not only in pancreatic ductal adenocarcinoma, but also in benign pancreatic tissue (Figure 2).
Gene_expression (expressed) of IGF-2 associated with adenocarcinoma
14) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.46 Pain Relevance 0
IGF-2 expression pattern and its correlation with IGF2BP3 expression
Gene_expression (expression) of IGF-2
15) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.48 Pain Relevance 0
Since the most studied IGF2BP3-regulated mRNA transcript is IGF-2, we examined the protein expression of IGF-2 in relation to that of IGF2BP3.
Spec (examined) Gene_expression (expression) of IGF-2
16) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.46 Pain Relevance 0
COX-2 mRNA and PGE2 levels are higher in proliferating cells compared with post-confluent differentiated cells and in cells that constitutively overexpress IGF-II.
Gene_expression (overexpress) of IGF-II
17) Confidence 0.51 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.38 Pain Relevance 0.08
In situ hybridization of the tumor samples demonstrated high expression of IGF II mRNA and elevated pro-IGF II (figure 3).
Gene_expression (expression) of IGF II associated with cancer
18) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.55 Pain Relevance 0
A landmark observation by Teale et al. was that IGF I and II levels in patients with hyperinsulinemic hypoglycemia were both usually low, while patients with NICTH had normal levels of IGF II [25].
Gene_expression (levels) of IGF II associated with hypoglycemia
19) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.74 Pain Relevance 0
In situ hybridization of the tumor samples demonstrated high expression of IGF II mRNA and elevated pro-IGF II (figure 3).
Gene_expression (expression) of pro-IGF II associated with cancer
20) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.55 Pain Relevance 0

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