INT252123

Context Info Confidence 0.28 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.62 Pain Relevance 0.10

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)

Anatomy Link Frequency neuronal 1 molecular layer 1 Dcx (Mus musculus)

Pain Link Frequency Relevance Heat Neuropeptide 14 82.56 Cholecystokinin 12 51.56 Eae 12 9.44 Hippocampus 10 5.00 Neurotransmitter 4 5.00 Pyramidal cell 4 5.00 Catecholamine 4 5.00 anesthesia 2 5.00 amygdala 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 4 98.72 Convulsion 26 91.92 Epilepsy 4 77.92 Stress 2 39.20 Cognitive Disorder 14 9.52 Anxiety Disorder 8 6.00 Targeted Disruption 14 5.00 Attention Deficit Hyperactivity Disorder 10 5.00 Body Weight 8 5.00 Tremor 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The number of DCx+ cell bodies was increased by 140% in the SGZ of neo-excised SNAP-25b deficient mice, including cells migrating through the granular cell layer, with a large increase in DCx+ fibers in the molecular layer (Figure 6R and 6T, c.f.

Positive_regulation (increase) of DCx in molecular layer

1) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.15 Pain Relevance 0.10

Both NPY and BDNF have been suggested to promote dentate SGZ neurogenesis [54],[55], and their elevated expression may contribute to the increase in DCx+ migrating neuronal precursor cells observed in our mutants.

Positive_regulation (increase) of DCx in neuronal associated with neurodegenerative disease

2) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.