INT252123

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)
Anatomy Link Frequency
neuronal 1
molecular layer 1
Dcx (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 14 82.56 Quite High
Cholecystokinin 12 51.56 Quite High
Eae 12 9.44 Low Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 4 98.72 Very High Very High Very High
Convulsion 26 91.92 High High
Epilepsy 4 77.92 Quite High
Stress 2 39.20 Quite Low
Cognitive Disorder 14 9.52 Low Low
Anxiety Disorder 8 6.00 Low Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Tremor 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of DCx+ cell bodies was increased by 140% in the SGZ of neo-excised SNAP-25b deficient mice, including cells migrating through the granular cell layer, with a large increase in DCx+ fibers in the molecular layer (Figure 6R and 6T, c.f.
Positive_regulation (increase) of DCx in molecular layer
1) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.15 Pain Relevance 0.10
Both NPY and BDNF have been suggested to promote dentate SGZ neurogenesis [54],[55], and their elevated expression may contribute to the increase in DCx+ migrating neuronal precursor cells observed in our mutants.
Positive_regulation (increase) of DCx in neuronal associated with neurodegenerative disease
2) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.48 Pain Relevance 0

General Comments

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