INT252127

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 2.76
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
neurons 4
bands 4
neuronal 2
spikes 2
brain 2
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 40 97.24 Very High Very High Very High
GABAergic 225 96.52 Very High Very High Very High
Hippocampus 75 88.32 High High
Neuropeptide 89 85.44 High High
Thalamus 20 84.48 Quite High
Neurotransmitter 79 81.76 Quite High
imagery 20 78.80 Quite High
Catecholamine 29 72.80 Quite High
amygdala 12 72.40 Quite High
Action potential 55 60.00 Quite High
Disease Link Frequency Relevance Heat
Convulsion 156 98.08 Very High Very High Very High
Diabetes Mellitus 154 97.20 Very High Very High Very High
Targeted Disruption 105 93.00 High High
Cognitive Disorder 84 92.12 High High
Intellectual Impairment 12 86.00 High High
Tremor 24 85.44 High High
Attention Deficit Hyperactivity Disorder 60 81.84 Quite High
Sprains And Strains 33 80.48 Quite High
Hyperglycemia 5 70.00 Quite High
Anxiety Disorder 48 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elimination of SNAP-25b expression resulted in developmental defects, spontaneous seizures, and impaired short-term synaptic plasticity.
Negative_regulation (Elimination) of Gene_expression (expression) of SNAP-25b associated with convulsion
1) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581893 Disease Relevance 0.10 Pain Relevance 0.09
Our results show, that homozygous neo-containing SNAP-25b deficient mice, lacking SNAP-25b expression and having a moderate reduction in total levels of SNAP-25 protein, exhibit severe developmental and behavioral defects.


Negative_regulation (lacking) of Gene_expression (expression) of SNAP-25b
2) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.16 Pain Relevance 0
The reduced SNAP-25 expression in neo-containing SNAP-25b deficient mutants could be due to the presence of the Tkneo selection gene.
Negative_regulation (reduced) of Gene_expression (expression) of SNAP-25
3) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.14 Pain Relevance 0
Thus, we have developed a SNAP-25b deficient mouse mutant by replacing exon 5b with an additional exon 5a equivalent, thereby preventing expression of SNAP-25b but not the alternative splicing.


Negative_regulation (preventing) of Gene_expression (expression) of SNAP-25b
4) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.08 Pain Relevance 0
The exon 5b was genetically eliminated and replaced with a second supplementary exon 5a, to maintain alternative splicing and normal expression levels, but allowing only SNAP-25a to be expressed.
Negative_regulation (allowing) of Gene_expression (expressed) of SNAP-25a
5) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.66 Pain Relevance 0.04
Acute interference of SNAP-25 expression has been reported to lead to increased depolarization-induced calcium transients in cultured neurons [8].
Negative_regulation (interference) of Gene_expression (expression) of SNAP-25 in neurons
6) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.26
Interestingly, the amplitude of spontaneous synchronous calcium spikes in cultures from heterozygous null mutants, expressing reduced levels of SNAP-25, did not differ substantially from wild type neurons.
Negative_regulation (reduced) of Gene_expression (expressing) of SNAP-25 in spikes
7) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.22
Our results demonstrate that absence of SNAP-25b reduces PPF at Schaffer collateral-CA1 synapses in PN12-16 mice during low-frequency stimulation.


Negative_regulation (reduces) of Neg (absence) Gene_expression (absence) of SNAP-25b in synapses
8) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.15 Pain Relevance 0.12
Boiling of the samples resulted in the loss of all immunoreactive bands except the monomeric SNAP-25 in both neo-excised SNAP-25b deficient and WT mice.
Negative_regulation (loss) of Neg (except) Gene_expression (deficient) of SNAP-25b in bands
9) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
The reduced SNAP-25 expression in neo-containing SNAP-25b deficient mutants could be due to the presence of the Tkneo selection gene.
Negative_regulation (reduced) of Gene_expression (expression) of SNAP-25b
10) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.14 Pain Relevance 0
Boiling of the samples resulted in the loss of all immunoreactive bands except the monomeric SNAP-25 in both neo-excised SNAP-25b deficient and WT mice.
Negative_regulation (loss) of Neg (except) Gene_expression (deficient) of SNAP-25 in bands
11) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
Our results demonstrate that removal of Tkneo restores SNAP-25 expression and moderately increases total SNAP-25 protein levels in brain of homozygous neo-excised SNAP-25b deficient mutants.


Negative_regulation (restores) of Gene_expression (expression) of SNAP-25 in brain
12) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.16 Pain Relevance 0
Reduced SNAP-25 protein levels in absence of SNAP-25b are lethal, as demonstrated in the homozygous neo-containing SNAP-25b deficient mutants.
Negative_regulation (absence) of Gene_expression (levels) of SNAP-25 protein
13) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.18 Pain Relevance 0.04
Reduced SNAP-25 protein levels in absence of SNAP-25b are lethal, as demonstrated in the homozygous neo-containing SNAP-25b deficient mutants.
Negative_regulation (Reduced) of Gene_expression (levels) of SNAP-25 protein
14) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.18 Pain Relevance 0.04
Using a more sensitive, quantitative qRT-PCR assay, we show here that the expression of SNAP-25a and 25b RNA transcripts compared to ?
Negative_regulation (compared) of Gene_expression (expression) of SNAP-25a
15) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.11
Ca2+ signaling in control and SNAP-25 deficient neurons
Negative_regulation (deficient) of Gene_expression (neurons) of SNAP-25 in neurons
16) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.12
Alterations of calcium dynamics in SNAP-25 deficient neuronal cultures
Negative_regulation (deficient) of Gene_expression (cultures) of SNAP-25 in neuronal
17) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.36
Decreased expression of t-snare, syntaxin 1, and snap-25 in pancreatic ß cells is involved in impaired insulin secretion from diabetic GK rat islets [24].
Negative_regulation (Decreased) of Gene_expression (expression) of snap-25 associated with diabetes mellitus
18) Confidence 0.20 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.82 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox