INT252131

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.33
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Anatomy Link Frequency
neuronal 1
plasma 1
GABAergic neurons 1
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 90 99.84 Very High Very High Very High
antidepressant 26 98.72 Very High Very High Very High
Glutamate 70 94.40 High High
Neurotransmitter 31 93.40 High High
Action potential 23 85.52 High High
Pyramidal cell 30 78.88 Quite High
Hippocampus 17 76.24 Quite High
Calcium channel 16 73.04 Quite High
Neuropeptide 16 50.32 Quite High
gABA 12 39.24 Quite Low
Disease Link Frequency Relevance Heat
Stress 111 97.78 Very High Very High Very High
Urological Neuroanatomy 6 50.00 Quite Low
Targeted Disruption 22 25.28 Quite Low
Embryonic Lethality 2 13.28 Low Low
Convulsion 26 5.00 Very Low Very Low Very Low
Cognitive Disorder 14 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While it has been demonstrated that SNAP-25 is expressed and required for stimulus-driven synaptic transmission by both glutamatergic and GABAergic neurons in fetal mouse brain and in culture [3,5,10,11], it has been also proposed that differential expression of this t-SNARE may lead to differences in calcium dynamics between inhibitory and excitatory synapses [8] and thereby possibly contribute to the physiological diversity observed between these neurons [for review, see [29]].
Gene_expression (expression) of t-SNARE in GABAergic neurons associated with gabaergic
1) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.09
In this study, we investigate the effects of SNAP-25 ablation on spontaneous neuronal activity and the expression of functionally distinct isoforms of this t-SNARE in GABAergic and glutamatergic neurons of the adult brain.


Gene_expression (expression) of t-SNARE in neuronal associated with gabaergic
2) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.41
The different stability of SNARE complexes found in neo-excised SNAP-25b deficient mutants compared to WT mice (Figure 2E) and that SNAP-25b demonstrates an increased association with plasma membrane fractions compared to SNAP-25a (see Text S1, Figure S2) suggest that SNAP-25a and SNAP-25b are differently associated with SNARE complexes close to, or immediately upstream of fusion.
Gene_expression (complexes) of SNARE in plasma
3) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.08
It is notable that the number of SNARE proteins, and alternative isoform variants, have increased through evolution and their expression is strictly regulated both anatomically and temporally [19]–[23].
Gene_expression (expression) of SNARE
4) Confidence 0.19 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.03
First, we measured SNARE complexes in drug-treated rats in basal conditions (without stress); we found that in P/FC chronic antidepressant treatments did not induce significant changes in the amount of SNARE complexes (Fig.
Gene_expression (complexes) of SNARE associated with stress and antidepressant
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.33 Pain Relevance 0.26

General Comments

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