INT252134

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.54
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
Purkinje cells 1
GABAergic neurons 1
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 45 99.48 Very High Very High Very High
Pyramidal cell 14 95.48 Very High Very High Very High
anesthesia 3 68.32 Quite High
Thalamus 4 64.40 Quite High
Hippocampus 18 62.16 Quite High
Action potential 11 50.00 Quite Low
Neuropeptide 22 5.00 Very Low Very Low Very Low
Cholecystokinin 18 5.00 Very Low Very Low Very Low
Eae 18 5.00 Very Low Very Low Very Low
Neurotransmitter 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 39 76.00 Quite High
Body Weight 12 68.56 Quite High
Targeted Disruption 25 12.24 Low Low
Cognitive Disorder 21 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 15 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Tremor 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In heterozygous neo-excised mutants the relative SNAP-25a/SNAP-25b mRNA ratio was 2?
Negative_regulation (relative) of Transcription (ratio) of SNAP-25b
1) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.27 Pain Relevance 0
Determination of SNAP-25a/b mRNA ratio expression was essentially performed as described [26] (and Text S1).
Negative_regulation (Determination) of Transcription (expression) of SNAP-25a
2) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.07
In heterozygous neo-excised mutants the relative SNAP-25a/SNAP-25b mRNA ratio was 2?
Negative_regulation (relative) of Transcription (ratio) of SNAP-25a
3) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.27 Pain Relevance 0
Moreover, SNAP-25a transcripts in Purkinje cells were also greatly decreased relative to GABAergic neurons of the reticular nucleus and the caudate, as well as hippocampal interneurons and pyramidal neurons (Fig. 5C).
Negative_regulation (decreased) of in GABAergic neurons Transcription (transcripts) of SNAP-25a in Purkinje cells associated with pyramidal cell and gabaergic
4) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.26

General Comments

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