INT252145

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.85
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) transport (Napb) vesicle-mediated transport (Napb)
plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
neurons 3
plasma 2
bands 1
Napb (Mus musculus)
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 45 99.12 Very High Very High Very High
Thalamus 4 91.40 High High
Pyramidal cell 24 78.08 Quite High
Neurotransmitter 27 77.52 Quite High
isoflurane 8 75.60 Quite High
Hippocampus 43 75.44 Quite High
Catecholamine 17 66.68 Quite High
Glutamate 2 61.36 Quite High
gABA 1 60.80 Quite High
Action potential 11 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ataxia 8 92.72 High High
Sprains And Strains 17 91.36 High High
Retina Disease 8 89.64 High High
Alcohol Intoxication 8 88.08 High High
Tremor 16 72.80 Quite High
Cognitive Disorder 56 55.72 Quite High
Convulsion 104 5.00 Very Low Very Low Very Low
Targeted Disruption 60 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 40 5.00 Very Low Very Low Very Low
Body Weight 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with other studies [5,10,11], these results provide additional evidence that SNAP-25b is a key component of the neural SNARE complex responsible for both GABAergic and glutamatergic transmission in mature neurons.


SNARE Binding (complex) of SNAP-25b in neurons associated with gabaergic
1) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.39
The different stability of SNARE complexes found in neo-excised SNAP-25b deficient mutants compared to WT mice (Figure 2E) and that SNAP-25b demonstrates an increased association with plasma membrane fractions compared to SNAP-25a (see Text S1, Figure S2) suggest that SNAP-25a and SNAP-25b are differently associated with SNARE complexes close to, or immediately upstream of fusion.
SNARE Binding (associated) of SNAP-25a in plasma
2) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.08
The different stability of SNARE complexes found in neo-excised SNAP-25b deficient mutants compared to WT mice (Figure 2E) and that SNAP-25b demonstrates an increased association with plasma membrane fractions compared to SNAP-25a (see Text S1, Figure S2) suggest that SNAP-25a and SNAP-25b are differently associated with SNARE complexes close to, or immediately upstream of fusion.
SNARE Binding (associated) of SNAP-25b in plasma
3) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.08
To measure the grade of disassembly of heat-resistant SNARE complex in WT and SNAP-25b KO tissue, percentage monomeric SNAP-25 protein of total SNAP-25 in ternary complex at 4°C was calculated and compared with the value calculated at a certain temperature.
SNARE Binding (complex) of SNAP-25
4) Confidence 0.12 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.04
To measure the grade of disassembly of heat-resistant SNARE complex in WT and SNAP-25b KO tissue, percentage monomeric SNAP-25 protein of total SNAP-25 in ternary complex at 4°C was calculated and compared with the value calculated at a certain temperature.
SNARE Binding (complex) of SNAP-25b
5) Confidence 0.12 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.04
500,000) was used to detect immunoreactivity of bands migrating as ternary SNARE complex or solitaire SNAP-25 protein.
SNARE Binding (complex) of SNAP-25 protein in bands
6) Confidence 0.12 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.03
In the SNARE complex with syntaxin and VAMP, SNAP-25 contributes with two amphipathic ?
SNARE Binding (complex) of SNAP-25
7) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.13 Pain Relevance 0.04
The SNAP-25b(Bdr) SNARE complexes, apparently more stable than complexes with WT SNAP-25b, result in impairment of both spontaneous and evoked release from cortical neurons and lack of facilitation during trains of high-frequency stimulation [48].
SNARE Binding (complexes) of SNAP-25b in neurons
8) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.36 Pain Relevance 0.03
The SNAP-25b(Bdr) SNARE complexes, apparently more stable than complexes with WT SNAP-25b, result in impairment of both spontaneous and evoked release from cortical neurons and lack of facilitation during trains of high-frequency stimulation [48].
SNARE Binding (complexes) of SNAP-25b in neurons
9) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.36 Pain Relevance 0.03

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