INT252171

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Trub1) RNA binding (Trub1) cellular_component (Trub1)
Anatomy Link Frequency
chondrocytes 1
muscle tissue 1
Trub1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 77.36 Quite High
Pain 3 70.84 Quite High
Inflammatory response 2 68.48 Quite High
cytokine 4 32.16 Quite Low
Inflammatory mediators 1 24.64 Low Low
cINOD 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polymyositis 10 98.60 Very High Very High Very High
Dermatomyositis 11 97.96 Very High Very High Very High
INFLAMMATION 43 77.36 Quite High
Pain 3 70.84 Quite High
Myositis 27 63.96 Quite High
Vasculitis 4 47.44 Quite Low
Bacterial Infection 6 44.64 Quite Low
Injury 6 38.88 Quite Low
Stress 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis

Objectives:

Gene_expression (expression) of E synthase 1 in muscle tissue associated with dermatomyositis and polymyositis
1) Confidence 0.01 Published 2008 Journal Annals of the Rheumatic Diseases Section Title Doc Link PMC2582339 Disease Relevance 0.74 Pain Relevance 0.07
Pretreatment with CoPP decreased PGE2 production by inhibiting microsomal prostaglandin E synthase-1 expression in primary cultured chondrocytes [25].
Gene_expression (expression) of E synthase-1 in chondrocytes
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.35 Pain Relevance 0.21

General Comments

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