INT252177

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0.14

cytoplasm (VEGFA, CPOX) mitochondrion (CPOX) small molecule metabolic process (CPOX) extracellular space (VEGFA) extracellular region (VEGFA) growth (VEGFA)

Anatomy Link Frequency T cells 2 VEGFA (Homo sapiens) CPOX (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 1 97.90 Inflammation 21 61.04 cINOD 3 19.40 cytokine 4 14.88 COX-2 inhibitor 5 5.00 rheumatoid arthritis 2 5.00 psoriasis 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Gastrointestinal Disease 1 74.20 Pathologic Neovascularization 2 72.56 Cancer 16 67.48 Inflammatory Bowel Disease 15 62.52 INFLAMMATION 19 61.04 Toxicity 2 54.96 Intestinal Polyposis 1 34.96 Lung Cancer 1 29.52 Adenocarcinoma 4 26.52 Adhesions 7 9.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previously, we have shown that VEGF leads to proliferation of HIMECs,24 triggering dephosphorylation, translocation and activation of NFAT (nuclear factor of activated T cells) in HIMECs.25 VEGF activates various signalling pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt, protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) cascades.26 However, the signalling pathways by which VEGF regulates COX expression in HIMECs are not fully characterised.

VEGF Regulation (regulates) of Gene_expression (expression) of COX in T cells associated with kinase c

1) Confidence 0.03 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.56 Pain Relevance 0.14

General Comments

This test has worked.