INT252177

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, CPOX) mitochondrion (CPOX) small molecule metabolic process (CPOX)
extracellular space (VEGFA) extracellular region (VEGFA) growth (VEGFA)
Anatomy Link Frequency
T cells 2
VEGFA (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 97.90 Very High Very High Very High
Inflammation 21 61.04 Quite High
cINOD 3 19.40 Low Low
cytokine 4 14.88 Low Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Disease 1 74.20 Quite High
Pathologic Neovascularization 2 72.56 Quite High
Cancer 16 67.48 Quite High
Inflammatory Bowel Disease 15 62.52 Quite High
INFLAMMATION 19 61.04 Quite High
Toxicity 2 54.96 Quite High
Intestinal Polyposis 1 34.96 Quite Low
Lung Cancer 1 29.52 Quite Low
Adenocarcinoma 4 26.52 Quite Low
Adhesions 7 9.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have shown that VEGF leads to proliferation of HIMECs,24 triggering dephosphorylation, translocation and activation of NFAT (nuclear factor of activated T cells) in HIMECs.25 VEGF activates various signalling pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt, protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) cascades.26 However, the signalling pathways by which VEGF regulates COX expression in HIMECs are not fully characterised.
VEGF Regulation (regulates) of Gene_expression (expression) of COX in T cells associated with kinase c
1) Confidence 0.03 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.56 Pain Relevance 0.14

General Comments

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