INT25220

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.78
Pain Relevance 7.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
dorsal horn 4
outflow 2
heart 2
vascular endothelium 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 156 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Arthritis 28 99.68 Very High Very High Very High
bradykinin 6 99.60 Very High Very High Very High
Deafferentation 2 99.50 Very High Very High Very High
qutenza 25 99.44 Very High Very High Very High
Pain 40 99.28 Very High Very High Very High
Morphine 11 98.88 Very High Very High Very High
Dorsal horn 12 98.60 Very High Very High Very High
noradrenaline 2 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 46 99.72 Very High Very High Very High
Hypoxia 24 99.72 Very High Very High Very High
Arthritis 60 99.68 Very High Very High Very High
Pain 39 99.28 Very High Very High Very High
Natriuresis 2 99.28 Very High Very High Very High
Heart Rate Under Development 1 98.20 Very High Very High Very High
Cv Unclassified Under Development 8 97.70 Very High Very High Very High
Poisoning 1 95.72 Very High Very High Very High
Hypotension 2 80.24 Quite High
Headache 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin treatment also significantly elevated vascular CGRP binding.
Positive_regulation (elevated) of CGRP Binding (binding) of associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.69 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666097 Disease Relevance 0.87 Pain Relevance 0.64
CGRP binding was seen in the vascular endothelium and was significantly elevated after 5 days of hypoxia (mean +/- SEM: control 4.6 +/- 0.4 versus hypoxic 16.6 +/- 2.4 amol.mm-2).
Positive_regulation (elevated) of CGRP Binding (binding) of in vascular endothelium associated with hypoxia and calcitonin gene-related peptide
2) Confidence 0.69 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666097 Disease Relevance 0.89 Pain Relevance 0.72
In fact, increases in CGRP-like immunostaining and decrements in specific [125]hCGRP binding in the superficial laminae of the dorsal horn were correlated with the development of tolerance to the spinal antinociceptive action of morphine.
Positive_regulation (increases) of CGRP Binding (binding) of in dorsal horn associated with tolerance, dorsal horn, antinociceptive, morphine and calcitonin gene-related peptide
3) Confidence 0.67 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8601814 Disease Relevance 0 Pain Relevance 1.42
Ten days after pronase-induced deafferentation there was a significant increase in SP and CGRP binding in the superficial (I-II) and deeper (II-IV) laminae of the dorsal horn ipsilaterally.
Positive_regulation (increase) of CGRP Binding (binding) of in dorsal horn associated with dorsal horn, calcitonin gene-related peptide, substance p and deafferentation
4) Confidence 0.44 Published 1999 Journal Somatosens Mot Res Section Abstract Doc Link 10355881 Disease Relevance 0.10 Pain Relevance 0.73
Synaptic facilitation by CGRP is enhanced in the arthritis pain model
Positive_regulation (enhanced) of CGRP Binding (facilitation) of associated with pain, arthritis and calcitonin gene-related peptide
5) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1592081 Disease Relevance 0.86 Pain Relevance 0.97
Among other agents tested, bradykinin and ouabain caused increased outflow of CGRP but not of NPY-LI.
Positive_regulation (increased) of CGRP Neg (not) Binding (outflow) of in outflow associated with bradykinin and calcitonin gene-related peptide
6) Confidence 0.41 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2784250 Disease Relevance 0.28 Pain Relevance 1.69
*P < 0.05

Calcitonin gene-related peptide induced dilation

Positive_regulation (induced) of Calcitonin gene-related peptide Binding (0.05) of associated with calcitonin gene-related peptide
7) Confidence 0.39 Published 2010 Journal J Headache Pain Section Body Doc Link PMC2995862 Disease Relevance 0.44 Pain Relevance 0.21
While ouabain markedly increased the contractile force, exposure to bradykinin or ischaemia did not induce any clear-cut changes in contractile force or heart rate. (4) Capsaicin-exposure evoked a markedly increased outflow of CGRP-LI but not of NPY-LI in combination with an increase in heart rate and a decrease in contractile force.
Positive_regulation (increased) of CGRP Spec (clear) Binding (outflow) of in heart associated with heart rate under development, qutenza, cv unclassified under development, bradykinin and calcitonin gene-related peptide
8) Confidence 0.19 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2509948 Disease Relevance 0.34 Pain Relevance 0.95

General Comments

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