INT252209

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 8.29
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Lgals3) nucleus (Lgals3) extracellular matrix organization (Lgals3)
cytoplasm (Lgals3)
Anatomy Link Frequency
macrophages 7
Schwann cells 4
plasma 2
middle cerebral artery 2
thymus 2
Lgals3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 100.00 Very High Very High Very High
Sciatic nerve 6 99.74 Very High Very High Very High
Peripheral nervous system 6 99.44 Very High Very High Very High
Inflammation 62 96.24 Very High Very High Very High
imagery 46 93.20 High High
fibrosis 115 86.96 High High
ischemia 6 86.88 High High
anesthesia 11 84.12 Quite High
metalloproteinase 52 80.80 Quite High
Nerve growth factor 144 75.96 Quite High
Disease Link Frequency Relevance Heat
Obesity 126 99.84 Very High Very High Very High
Coronary Heart Disease 7 99.62 Very High Very High Very High
Cancer 102 99.42 Very High Very High Very High
Acute Decompensated Heart Failure (ADHF) 20 98.20 Very High Very High Very High
Middle Cerebral Artery Infarction 6 97.32 Very High Very High Very High
Injury 140 97.04 Very High Very High Very High
Apoptosis 47 96.80 Very High Very High Very High
INFLAMMATION 68 96.24 Very High Very High Very High
Thyroid Nodule 12 91.00 High High
Cv Unclassified Under Development 11 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression levels of galectin-3 are associated with the tendency to develop decompensated heart failure, and in clinical cohorts, increased plasma galectin-3 levels are linked with worse prognosis.
Positive_regulation (increased) of in heart Gene_expression (expression) of galectin-3 in plasma associated with acute decompensated heart failure (adhf)
1) Confidence 0.57 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.32 Pain Relevance 0.03
To determine the in vivo expression of galectin-3 in tumor xenografts, some of the tumors were surgically excised and used for galectin-3 expression analysis as reported above.
Positive_regulation (used) of Gene_expression (expression) of galectin-3 associated with cancer
2) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.73 Pain Relevance 0.13
A forced expression of galectin-3 via specific cDNA transfection generates a transformed phenotype, blocking the apoptotic program, a feature that favors the development of cancer [5]–[9].
Positive_regulation (forced) of Gene_expression (expression) of galectin-3 associated with cancer and apoptosis
3) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.79 Pain Relevance 0
In the murine peripheral nervous system, sciatic nerve transection induces Schwann cells to express galectin-3/Mac-2 and phagocytose myelin [22].
Positive_regulation (induces) of Gene_expression (express) of galectin-3 in Schwann cells associated with peripheral nervous system and sciatic nerve
4) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.84 Pain Relevance 0.27
Long term upregulation of both IBA-1-ir and galectin-3/Mac-2-ir microglia has also been observed in the subventricular zone (SVZ) following middle cerebral artery occlusion [18].
Positive_regulation (upregulation) of Gene_expression (microglia) of galectin-3/Mac-2-ir in middle cerebral artery associated with middle cerebral artery infarction
5) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.73 Pain Relevance 0.15
In the murine peripheral nervous system, sciatic nerve transection induces Schwann cells to express galectin-3/Mac-2 and phagocytose myelin [22].
Positive_regulation (induces) of Gene_expression (express) of Mac-2 in Schwann cells associated with peripheral nervous system and sciatic nerve
6) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.84 Pain Relevance 0.27
Mechanistic studies have provided evidence that cardiac fibroblasts and macrophages are the main sources for galectin-3, and that the TGF-?
Positive_regulation (macrophages) of in fibroblasts Gene_expression (sources) of galectin-3 in macrophages
7) Confidence 0.41 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.50 Pain Relevance 0.12
in their livers develop myocarditis, with macrophages expressing high levels of galectin-3 [42].


Positive_regulation (levels) of Gene_expression (expressing) of galectin-3 in macrophages associated with coronary heart disease
8) Confidence 0.38 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 1.17 Pain Relevance 0.43
The increased expression levels of galectin-3 are associated with the tendency to develop decompensated heart failure, and in clinical cohorts, increased plasma galectin-3 levels are linked with worse prognosis.
Positive_regulation (increased) of in heart Gene_expression (levels) of galectin-3 in plasma associated with acute decompensated heart failure (adhf)
9) Confidence 0.38 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.32 Pain Relevance 0.03
Mechanistic studies have provided evidence that cardiac fibroblasts and macrophages are the main sources for galectin-3, and that the TGF-?
Positive_regulation (macrophages) of Gene_expression (sources) of galectin-3 in macrophages
10) Confidence 0.14 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.50 Pain Relevance 0.12
Thus, the reduced F4/80 mRNA and Mac-2 antigen expression in WAT in the presence of unaltered macrophage-autonomous marker gene expression clearly provides independent experimental evidence for reduced macrophage recruitment to WAT of IR?
Positive_regulation (antigen) of Gene_expression (expression) of Mac-2 in macrophage associated with obesity
11) Confidence 0.14 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.22 Pain Relevance 0
Several studies demonstrated that in these animals the thymus exhibits enhanced deposition of extracellular matrix proteins such as fibronectin, laminin, and type IV collagen, increased chemokine contents such as CXCL12, and expression of de-adhesive molecules such as galectin-3.
Positive_regulation (enhanced) of Gene_expression (expression) of galectin-3 in thymus associated with chemokine
12) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.34 Pain Relevance 0.05

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