INT252211

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.82
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Lgals3) nucleus (Lgals3) extracellular matrix organization (Lgals3)
cytoplasm (Lgals3)
Anatomy Link Frequency
middle cerebral artery 2
macrophages 1
thyroid 1
Lgals3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 69 100.00 Very High Very High Very High
metalloproteinase 44 100.00 Very High Very High Very High
imagery 25 79.20 Quite High
Spinal cord 10 68.60 Quite High
Demyelination 2 67.68 Quite High
Nerve growth factor 96 50.00 Quite Low
Inflammation 50 50.00 Quite Low
Sciatic nerve 4 37.84 Quite Low
Inflammatory response 6 37.40 Quite Low
Peripheral nervous system 4 37.24 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 60 100.00 Very High Very High Very High
Targeted Disruption 6 99.44 Very High Very High Very High
Obesity 126 99.24 Very High Very High Very High
Malignant Neoplastic Disease 8 98.92 Very High Very High Very High
Cancer 54 98.00 Very High Very High Very High
Middle Cerebral Artery Infarction 4 95.44 Very High Very High Very High
Myocardial Infarction 99 95.28 Very High Very High Very High
Injury 93 94.60 High High
Diffuse Axonal Injury 16 92.88 High High
Thyroid Neoplasm 22 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the thyroid origin of ARO cells has been recently questioned [20], this galectin-3 positive cell line grows very efficiently in vivo and provides an useful model for setting experiments of galectin-3 immunotargeting with and without galectin-3 mRNA interference.
Neg (without) Negative_regulation (interference) of galectin-3 in thyroid
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.56 Pain Relevance 0.08
Selective ablation of galectin-3/Mac-2-positive microglia in transgenic mice was associated with an increase in the size of the infarct zone following transient middle cerebral artery occlusion [16].
Negative_regulation (ablation) of galectin-3 in middle cerebral artery associated with targeted disruption and middle cerebral artery infarction
2) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.80 Pain Relevance 0.07
Selective ablation of galectin-3/Mac-2-positive microglia in transgenic mice was associated with an increase in the size of the infarct zone following transient middle cerebral artery occlusion [16].
Negative_regulation (ablation) of Mac-2-positive in middle cerebral artery associated with targeted disruption and middle cerebral artery infarction
3) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.81 Pain Relevance 0.07
Further study is warranted, however, because it is currently unknown whether long-term treatments (eg, ACE inhibitors and aldosterone receptor blockers) intended to reduce matrix apposition and fibrosis lower galectin-3 levels.
Negative_regulation (reduce) of galectin-3 associated with fibrosis
4) Confidence 0.36 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.63 Pain Relevance 0.05
Second, the authors reported that no fibrosis-related biomarkers, such as tissue inhibitor of metalloproteinases-1 (TIMP-1), tenascin, osteopontin, or galectin-3, were reduced by MCS; only the loading-related biomarker BNP was reduced by MCS.
Negative_regulation (inhibitor) of galectin-3 associated with fibrosis and metalloproteinase
5) Confidence 0.36 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.71 Pain Relevance 0.22
Loss of nuclear galectin-3 is believed to affect the malignant phenotype of cancers.
Negative_regulation (Loss) of galectin-3 associated with malignant neoplastic disease and cancer
6) Confidence 0.36 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.20 Pain Relevance 0
However, in line with the reduced mRNA expression of macrophage marker genes, immunohistochemical analysis of infiltrating, activated macrophages demonstrated a striking reduction of Mac-2-positive cells in WAT of diet-induced obese IR?
Negative_regulation (reduction) of Mac-2 in macrophages associated with obesity
7) Confidence 0.12 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox