INT252212

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 4.82
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Lgals3) nucleus (Lgals3) extracellular matrix organization (Lgals3)
cytoplasm (Lgals3)
Anatomy Link Frequency
spinal cord 6
optic nerve 2
heart 2
Lgals3 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 20 98.68 Very High Very High Very High
Demyelination 4 98.22 Very High Very High Very High
fibrosis 23 95.64 Very High Very High Very High
Sciatic nerve 8 66.60 Quite High
Peripheral nervous system 8 66.00 Quite High
imagery 67 63.28 Quite High
ischemia 8 54.00 Quite High
Nerve growth factor 192 50.00 Quite Low
Inflammation 12 27.80 Quite Low
Central nervous system 8 27.28 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 33 99.60 Very High Very High Very High
Demyelinating Disease 4 98.22 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 8 97.58 Very High Very High Very High
Cancer 122 96.12 Very High Very High Very High
Fibrosis 20 95.64 Very High Very High Very High
Optic Nerve Injuries 4 87.40 High High
Brain Injury 188 79.04 Quite High
Injury 181 74.24 Quite High
Disease 2 73.36 Quite High
Thyroid Neoplasm 66 68.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of Galectin-3 expression was checked in western blot analysis at different time points (12–72 hrs after transfection and tumour cells injection in mice).


Negative_regulation (Down) of Gene_expression (expression) of Galectin-3 associated with cancer
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.10 Pain Relevance 0
Down-regulation of Galectin-3 expression was checked in western blot analysis at different time points (12–72 hrs after transfection and tumour cells injection in mice).


Negative_regulation (regulation) of Gene_expression (expression) of Galectin-3 associated with cancer
2) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.10 Pain Relevance 0
The two following sequences, which strongly and similarly down regulated galectin-3 expression in ARO cells were sub-cloned into pSUPER vector and used interchangeably (conserved motifs are underlined): 5?
Negative_regulation (down) of Gene_expression (expression) of galectin-3
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.32 Pain Relevance 0.06
In contrast, after experimental allergic encephalomyelitis in mice, sites of demyelination within the spinal cord and optic nerve with active myelin degeneration and phagocytosis displayed robust expression of galectin-3/Mac-2 by resident microglia [23].
Negative_regulation (displayed) of Gene_expression (expression) of Mac-2 in spinal cord associated with demyelination, experimental autoimmune encephalomyelitis and spinal cord
4) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.92 Pain Relevance 0.19
In contrast, after experimental allergic encephalomyelitis in mice, sites of demyelination within the spinal cord and optic nerve with active myelin degeneration and phagocytosis displayed robust expression of galectin-3/Mac-2 by resident microglia [23].
Negative_regulation (displayed) of Gene_expression (expression) of galectin-3 in spinal cord associated with demyelination, experimental autoimmune encephalomyelitis and spinal cord
5) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.92 Pain Relevance 0.19
If it is indeed proven that standard treatment of heart failure is associated with lowering of galectin-3 expression and levels, one could argue that galectin-3 itself could also be a target for therapy.
Negative_regulation (lowering) of Gene_expression (expression) of galectin-3 in heart associated with myocardial infarction
6) Confidence 0.35 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.64 Pain Relevance 0.05
In contrast, after experimental allergic encephalomyelitis in mice, sites of demyelination within the spinal cord and optic nerve with active myelin degeneration and phagocytosis displayed robust expression of galectin-3/Mac-2 by resident microglia [23].
Negative_regulation (displayed) of in optic nerve Gene_expression (expression) of galectin-3 in spinal cord associated with demyelination, experimental autoimmune encephalomyelitis and spinal cord
7) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.92 Pain Relevance 0.19
In contrast, after experimental allergic encephalomyelitis in mice, sites of demyelination within the spinal cord and optic nerve with active myelin degeneration and phagocytosis displayed robust expression of galectin-3/Mac-2 by resident microglia [23].
Negative_regulation (displayed) of in optic nerve Gene_expression (expression) of Mac-2 in spinal cord associated with demyelination, experimental autoimmune encephalomyelitis and spinal cord
8) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.92 Pain Relevance 0.19

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