INT25222

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 24.18
Pain Relevance 19.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
PNS 12
sciatic nerves 6
peritoneal macrophages 4
neurons 4
T cells 4
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 57 100.00 Very High Very High Very High
cytokine 49 100.00 Very High Very High Very High
Chronic pancreatitis 6 100.00 Very High Very High Very High
Neuritis 117 99.98 Very High Very High Very High
fluoxetine 16 99.98 Very High Very High Very High
nud 4 99.84 Very High Very High Very High
spinal inflammation 9 99.78 Very High Very High Very High
Demyelination 6 99.76 Very High Very High Very High
Sciatic nerve 5 99.68 Very High Very High Very High
Inflammation 55 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 8 100.00 Very High Very High Very High
Cancer 8 100.00 Very High Very High Very High
Pancreatitis 7 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 117 99.98 Very High Very High Very High
Dyspepsia 4 99.84 Very High Very High Very High
Low Back Pain 9 99.78 Very High Very High Very High
Demyelinating Disease 17 99.76 Very High Very High Very High
INFLAMMATION 57 99.40 Very High Very High Very High
Anxiety Disorder 2 98.48 Very High Very High Very High
Disease 6 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronically stressed rats also exhibited anxiety-like behaviors, enhanced fecal pellet excretion, and small but significant increases in the mast cell numbers and the expression of IL-1beta and IFN-gamma.
Positive_regulation (increases) of Gene_expression (expression) of IFN-gamma in mast cell associated with anxiety disorder
1) Confidence 0.50 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15746211 Disease Relevance 1.59 Pain Relevance 0.26
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IFN-gamma
2) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.17
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Positive_regulation (induced) of Gene_expression (overexpression) of IFN-gamma
3) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.17
On the contrary, severe inflammation and demyelination as well as upregulated IFN-gamma and TNF-alpha production were observed in sciatic nerves of the same EAN rats.
Positive_regulation (upregulated) of Gene_expression (production) of IFN-gamma in sciatic nerves associated with demyelination, inflammation, sciatic nerve and neuritis
4) Confidence 0.48 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12864976 Disease Relevance 1.92 Pain Relevance 1.27
Splenocytes of Intact females showed higher IFN-gamma production than those of Intact males.
Positive_regulation (higher) of Gene_expression (production) of IFN-gamma
5) Confidence 0.47 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.15 Pain Relevance 0.21
Immune function was measured as mitogen-induced Interferon-gamma (IFN-gamma) production by splenocytes.
Positive_regulation (mitogen-induced) of Gene_expression (production) of Interferon-gamma
6) Confidence 0.46 Published 1993 Journal Psychoneuroendocrinology Section Abstract Doc Link 8390699 Disease Relevance 0.28 Pain Relevance 0.20
Immune function was measured as mitogen-induced Interferon-gamma (IFN-gamma) production by splenocytes.
Positive_regulation (mitogen-induced) of Gene_expression (production) of IFN-gamma
7) Confidence 0.46 Published 1993 Journal Psychoneuroendocrinology Section Abstract Doc Link 8390699 Disease Relevance 0.28 Pain Relevance 0.20
This study examined the modulation of IFN-gamma induced MHC class I and II expression on normal Lewis rats and rats with EAN peritoneal macrophages cultured in the absence or presence of 10(-4)-10(-8) M of the 5-HT reuptake inhibiting antidepressants zimeldine, and its metabolites norzimeldine and cpp200 oxalate as well as the antidepressants clomipramine and imipramine, in addition amitriptyline, nortriptyline and maprotiline in EAN rats.
Spec (examined) Positive_regulation (induced) of Gene_expression (expression) of IFN-gamma in peritoneal macrophages associated with nortriptyline, antidepressant, endep and neuritis
8) Confidence 0.43 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.33 Pain Relevance 0.62
During exposure to volatile anesthetics, gene expression for IL-1beta, MIP-2, IFN-gamma, and TNF-alpha all increased significantly compared with mechanical ventilation alone.
Positive_regulation (increased) of Gene_expression (expression) of IFN-gamma
9) Confidence 0.38 Published 1999 Journal Anesthesiology Section Body Doc Link 10422944 Disease Relevance 0 Pain Relevance 0
High levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were also detected, and both these cytokines can be harmful to several types of CNS cells, including neurons.
Positive_regulation (levels) of Gene_expression (detected) of interferon-gamma in neurons associated with necrosis, cancer and cytokine
10) Confidence 0.37 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.74 Pain Relevance 0.13
Lewis rats with EAN have elevated PNS myelin-reactive interferon-gamma (IFN-gamma) production, TNF-alpha mRNA expression, and increased B cell responses to PNS myelin antigens, but low PNS myelin-reactive transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 mRNA expression in lymph node mononuclear cells (MNC).
Positive_regulation (reactive) of Gene_expression (production) of IFN-gamma in PNS associated with peripheral nervous system and neuritis
11) Confidence 0.34 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.16 Pain Relevance 1.16
Lewis rats with EAN have elevated PNS myelin-reactive interferon-gamma (IFN-gamma) production, TNF-alpha mRNA expression, and increased B cell responses to PNS myelin antigens, but low PNS myelin-reactive transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 mRNA expression in lymph node mononuclear cells (MNC).
Positive_regulation (reactive) of Gene_expression (production) of interferon-gamma in PNS associated with peripheral nervous system and neuritis
12) Confidence 0.34 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.16 Pain Relevance 1.16
Lewis rats with EAN have elevated PNS myelin-reactive interferon-gamma (IFN-gamma) production, TNF-alpha mRNA expression, and increased B cell responses to PNS myelin antigens, but low PNS myelin-reactive transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 mRNA expression in lymph node mononuclear cells (MNC).
Positive_regulation (have) of Gene_expression (production) of interferon-gamma in PNS associated with peripheral nervous system and neuritis
13) Confidence 0.34 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.17 Pain Relevance 1.17
Lewis rats with EAN have elevated PNS myelin-reactive interferon-gamma (IFN-gamma) production, TNF-alpha mRNA expression, and increased B cell responses to PNS myelin antigens, but low PNS myelin-reactive transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 mRNA expression in lymph node mononuclear cells (MNC).
Positive_regulation (elevated) of Gene_expression (production) of IFN-gamma in PNS associated with peripheral nervous system and neuritis
14) Confidence 0.34 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.17 Pain Relevance 1.16
Lewis rats with EAN have elevated PNS myelin-reactive interferon-gamma (IFN-gamma) production, TNF-alpha mRNA expression, and increased B cell responses to PNS myelin antigens, but low PNS myelin-reactive transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 mRNA expression in lymph node mononuclear cells (MNC).
Positive_regulation (have) of Gene_expression (production) of IFN-gamma in PNS associated with peripheral nervous system and neuritis
15) Confidence 0.34 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.17 Pain Relevance 1.17
Lewis rats with EAN have elevated PNS myelin-reactive interferon-gamma (IFN-gamma) production, TNF-alpha mRNA expression, and increased B cell responses to PNS myelin antigens, but low PNS myelin-reactive transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 mRNA expression in lymph node mononuclear cells (MNC).
Positive_regulation (elevated) of Gene_expression (production) of interferon-gamma in PNS associated with peripheral nervous system and neuritis
16) Confidence 0.34 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.17 Pain Relevance 1.16
High levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were also detected, and both these cytokines can be harmful to several types of CNS cells, including neurons.
Positive_regulation (levels) of Gene_expression (detected) of IFN-gamma in neurons associated with necrosis, cancer and cytokine
17) Confidence 0.33 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.74 Pain Relevance 0.13
Expression of tumor necrosis factor-alpha, interleukin-6, and interferon-gamma in spontaneous chronic pancreatitis in the WBN/Kob rat.
Positive_regulation (pancreatitis) of Gene_expression (Expression) of interferon-gamma associated with necrosis, cancer and chronic pancreatitis
18) Confidence 0.31 Published 2001 Journal Pancreas Section Title Doc Link 11345142 Disease Relevance 1.12 Pain Relevance 0.71
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (levels) of Gene_expression (production) of interferon-gamma in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
19) Confidence 0.28 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.61 Pain Relevance 1.33
Autoantibodies to IFN-gamma dose-dependently inhibited IFN-gamma-induced MHC expression by peritoneal macrophages proving a neutralizing biological effect of these autoantibodies.
Positive_regulation (induced) of Gene_expression (expression) of IFN-gamma-induced in peritoneal macrophages
20) Confidence 0.26 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 0.97 Pain Relevance 1.10

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