INT252223

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 3
Total Number 19
Disease Relevance 10.28
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
liver 8
hepatocytes 6
adipocytes 4
fibroblasts 2
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 41 99.18 Very High Very High Very High
noradrenaline 28 85.84 High High
Catecholamine 24 67.60 Quite High
antagonist 4 49.84 Quite Low
agonist 27 47.56 Quite Low
Bile 110 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
fibrosis 15 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
headache 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 178 99.96 Very High Very High Very High
Hyperlipoproteinemia Type Ii 991 99.80 Very High Very High Very High
Hepatocellular Cancer 16 99.64 Very High Very High Very High
INFLAMMATION 41 99.18 Very High Very High Very High
Cytomegalovirus Infection 105 99.04 Very High Very High Very High
Disorder Of Lipid Metabolism 589 98.88 Very High Very High Very High
Hypertriglyceridemia 4 98.66 Very High Very High Very High
Diabetes Mellitus 34 97.28 Very High Very High Very High
Targeted Disruption 231 96.48 Very High Very High Very High
Hyperlipidemia 288 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This accumulation resulted from non-physiological over-expression of LDLR mediated by the Ad vector, causing pathological intracellular accumulation of the lipid that could not be compensated by the hepatic cell metabolism [133,134].
Positive_regulation (mediated) of Gene_expression (over) of LDLR
1) Confidence 0.55 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.34 Pain Relevance 0
The utility of replication defective first-generation recombinant Ad to mediate hLDLR gene transfer in hepatocytes derived from FH patients was first examined and documented in 1993 [123], using the ?
Positive_regulation (mediate) of Gene_expression (transfer) of hLDLR in hepatocytes associated with hyperlipoproteinemia type ii
2) Confidence 0.55 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.48 Pain Relevance 0
This vector construct was able to mediate LDLR expression at significant levels in the CHOldlA7 cells and in human fibroblasts derived from FH patients for 3 months and to retain the classical expression regulation by sterol levels in these cells.
Positive_regulation (mediate) of Gene_expression (expression) of LDLR in fibroblasts associated with hyperlipoproteinemia type ii
3) Confidence 0.55 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.34 Pain Relevance 0
Kinetic studies of the LDL metabolism demonstrated that LDL catabolism was increased in the same patient, which was consistent with increased LDLR expression [121].
Positive_regulation (increased) of Gene_expression (expression) of LDLR
4) Confidence 0.55 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.20 Pain Relevance 0
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Spec (investigated) Positive_regulation (Since) of Gene_expression (expressed) of LDLR in adipocytes associated with obesity
5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.69 Pain Relevance 0.15
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Spec (investigated) Positive_regulation (Since) of Gene_expression (expressed) of LDL receptor in adipocytes associated with obesity
6) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.69 Pain Relevance 0.15
However, the high level of LDLR expression and substantial reduction of total and LDL cholesterol achieved by adenovirus LDLR gene transfer in these animal models led to a massive intracellular lipid (cholesterol and cholesterol ester) deposition in transduced cells [130,133].
Positive_regulation (transfer) of Gene_expression (transfer) of LDLR gene
7) Confidence 0.48 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.44 Pain Relevance 0
The utility of replication defective first-generation recombinant Ad to mediate hLDLR gene transfer in hepatocytes derived from FH patients was first examined and documented in 1993 [123], using the ?
Positive_regulation (transfer) of Gene_expression (transfer) of hLDLR in hepatocytes associated with hyperlipoproteinemia type ii
8) Confidence 0.40 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.48 Pain Relevance 0
To date, IDLVs have not been used for LDLR gene transfer and FH gene therapy.
Positive_regulation (transfer) of Gene_expression (transfer) of LDLR gene associated with hyperlipoproteinemia type ii
9) Confidence 0.40 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.39 Pain Relevance 0
To date, IDLVs have not been used for LDLR gene transfer and FH gene therapy.
Neg (not) Positive_regulation (used) of Gene_expression (transfer) of LDLR gene associated with hyperlipoproteinemia type ii
10) Confidence 0.40 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.39 Pain Relevance 0
In an attempt to address this issue, Jacobs and colleagues investigated the use of a relatively low dose (5 × 1010 particles) of second generation E1E3E4-deleted adenoviral vectors for transfer of the LDLR or VLDLR, under control of the hepatocyte-specific human ?
Positive_regulation (transfer) of Gene_expression (transfer) of LDLR in hepatocyte
11) Confidence 0.37 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.43 Pain Relevance 0.03
This accumulation resulted from non-physiological over-expression of LDLR mediated by the Ad vector, causing pathological intracellular accumulation of the lipid that could not be compensated by the hepatic cell metabolism [133,134].
Positive_regulation (mediated) of Gene_expression (expression) of LDLR
12) Confidence 0.37 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.33 Pain Relevance 0
Similarly, injection of a replication-defective Ad encoding the hLDLR driven by an optimised CMV promoter into the portal vein of WHHL rabbits, resulted in over-expression of hLDLR in the majority of hepatocytes that exceeded the levels in normal human liver by at least 10 fold.
Positive_regulation (resulted) of Gene_expression (expression) of hLDLR in liver associated with cytomegalovirus infection
13) Confidence 0.37 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.57 Pain Relevance 0
Similarly, injection of a replication-defective Ad encoding the hLDLR driven by an optimised CMV promoter into the portal vein of WHHL rabbits, resulted in over-expression of hLDLR in the majority of hepatocytes that exceeded the levels in normal human liver by at least 10 fold.
Positive_regulation (resulted) of Gene_expression (over) of hLDLR in liver associated with cytomegalovirus infection
14) Confidence 0.37 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.57 Pain Relevance 0
After successful re-infusion of transduced cells through a catheter placed in the inferior mesenteric vein at the time of liver resection, only low-level expression of the transferred LDLR gene was observed in the five patients enrolled in the trial.
Positive_regulation (transferred) of Gene_expression (expression) of LDLR gene in liver
15) Confidence 0.37 Published 2010 Journal Int Arch Med Section Abstract Doc Link PMC3016243 Disease Relevance 0.91 Pain Relevance 0
After successful re-infusion of transduced cells through a catheter placed in the inferior mesenteric vein at the time of liver resection, only low-level expression of the transferred LDLR gene was observed in the five patients enrolled in the trial.
Positive_regulation (transferred) of Gene_expression (transferred) of LDLR gene in liver
16) Confidence 0.37 Published 2010 Journal Int Arch Med Section Abstract Doc Link PMC3016243 Disease Relevance 0.91 Pain Relevance 0
The antibody titre in the high-dose experiments was significantly above background, but was three orders of magnitude lower than that seen following first generation Ad-LDLR treatment, indicating that the marked pro-inflammatory adenoviral protein expression following FG-Ad-LDLR gene transfer could have acted as an adjuvant that stimulated antibody production in these mice.
Positive_regulation (transfer) of Gene_expression (transfer) of FG-Ad-LDLR associated with inflammation
17) Confidence 0.32 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.18 Pain Relevance 0.05
Using human hepatoma cells, berberine upregulated LDLR expression independent of sterol regulatory element binding proteins but was dependent on ERK activation [46].
Positive_regulation (upregulated) of Gene_expression (expression) of LDLR associated with hepatocellular cancer
18) Confidence 0.24 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.29 Pain Relevance 0
The 2004 update to the NCEP ATP III guidelines has the following additional recommendation: ‘For those high-risk patients who have elevated triglycerides or low HDL levels, addition of a fibrate or nicotinic acid to the routine LDL-lowering therapy can be considered’.23


Positive_regulation (routine) of Gene_expression (therapy) of LDL-lowering associated with hypertriglyceridemia and disorder of lipid metabolism
19) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.55 Pain Relevance 0

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