INT25223

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 41
Total Number 42
Disease Relevance 36.97
Pain Relevance 15.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
T cells 13
monocytes 7
lymphocytes 6
mononuclear cell 6
blood 5
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 312 100.00 Very High Very High Very High
cytokine 292 100.00 Very High Very High Very High
Morphine 25 99.98 Very High Very High Very High
abdominal pain 9 99.64 Very High Very High Very High
opioid receptor 2 99.44 Very High Very High Very High
cINOD 38 99.32 Very High Very High Very High
depression 12 99.24 Very High Very High Very High
agonist 17 98.80 Very High Very High Very High
Crohn's disease 7 98.28 Very High Very High Very High
spinal inflammation 18 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 353 100.00 Very High Very High Very High
Pulmonary Disease 113 100.00 Very High Very High Very High
Abdominal Pain 9 99.64 Very High Very High Very High
Critical Illness 38 99.32 Very High Very High Very High
Depression 10 99.24 Very High Very High Very High
Bacterial Respiratory Disease 7 99.24 Very High Very High Very High
Fever 24 99.10 Very High Very High Very High
Infection 128 99.00 Very High Very High Very High
Gastritis 20 99.00 Very High Very High Very High
Acute Disease 1 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced interferon-gamma production by lymphocytes induced by a mitogen from mycoplasma arthritidis in patients with ankylosing spondylitis.
Positive_regulation (Enhanced) of Gene_expression (production) of interferon-gamma in lymphocytes associated with spinal inflammation and bacterial respiratory disease
1) Confidence 0.67 Published 1989 Journal Rheumatol. Int. Section Title Doc Link 2510239 Disease Relevance 0.66 Pain Relevance 0.38
We found a significant increase of IFNgamma and TNFalpha production (p<0.01) and a significant decrease of IL-10 production (p<0.01) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Positive_regulation (increase) of Gene_expression (production) of IFNgamma associated with angina and myocardial infarction
2) Confidence 0.67 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 16216352 Disease Relevance 1.91 Pain Relevance 1.01
DC vaccination-induced interferon-gamma production is positively correlated with the number of antigen-specific T cells generated.
Positive_regulation (induced) of Gene_expression (production) of interferon-gamma in T cells
3) Confidence 0.64 Published 2009 Journal Stem Cells Section Abstract Doc Link 19536809 Disease Relevance 0.96 Pain Relevance 0.06
LPS or IFN-gamma activation of uninfected monocytes produced substantially higher levels of Quin than found in similarly stimulated HIV-1-infected monocytes.
Positive_regulation (levels) of Gene_expression (produced) of IFN-gamma in monocytes associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.50 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8799202 Disease Relevance 1.60 Pain Relevance 0.07
In murine macrophages, GPR109A expression is upregulated by cytokines such as interferon-gamma (IFN-?)
Positive_regulation (upregulated) of Gene_expression (cytokines) of interferon-gamma in macrophages associated with cytokine
5) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.89 Pain Relevance 0.10
We found a significant increase of IFNgamma and TNFalpha production (P<0.01) and a significant decrease of IL10 production (P<0.05) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Positive_regulation (increase) of Gene_expression (production) of IFNgamma associated with angina and myocardial infarction
6) Confidence 0.49 Published 2006 Journal Clin. Exp. Med. Section Abstract Doc Link 16550343 Disease Relevance 1.59 Pain Relevance 0.61
Enhanced interferon-gamma production by lymphocytes induced by a mitogen from mycoplasma arthritidis in patients with ankylosing spondylitis.
Positive_regulation (induced) of Gene_expression (production) of interferon-gamma in lymphocytes associated with spinal inflammation and bacterial respiratory disease
7) Confidence 0.49 Published 1989 Journal Rheumatol. Int. Section Title Doc Link 2510239 Disease Relevance 0.66 Pain Relevance 0.38
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes.
Positive_regulation (results) of in blood Gene_expression (production) of interferon-gamma in respiratory associated with morphine
8) Confidence 0.46 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0 Pain Relevance 0.55
Despite the high levels of IFN gamma expression, the viability of the coinfected cells in the presence of morphine was maintained.
Positive_regulation (levels) of Gene_expression (expression) of IFN gamma associated with morphine
9) Confidence 0.46 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.21 Pain Relevance 1.23
Furthermore, tenidap was found to inhibit IFN-gamma production as well as the induction of mRNA encoding IFN-gamma or TNF-alpha.
Positive_regulation (induction) of Gene_expression (production) of IFN-gamma
10) Confidence 0.46 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 8552993 Disease Relevance 0.57 Pain Relevance 0.50
In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells. [3H]thymidine uptake and interferon gamma production were increased by the delta-opioid receptor agonist, deltorphin-I (10(-14)-10(-10) M) and by the delta-opioid antagonist naltrindole (10(-13)-10(-9) M).
Positive_regulation (increased) of Gene_expression (production) of interferon gamma in mononuclear cells associated with antagonist, agonist, opioid receptor and opioid
11) Confidence 0.40 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9286627 Disease Relevance 0 Pain Relevance 0.28
Several cases of liver injury related to administration of drugs appear to be initiated or intensified by upper respiratory febrile illnesses and/or inflammation states, which stimulate sometimes dysregulated production of interferon gamma and/or other proinflammatory cytokines/growth factors.
Positive_regulation (stimulate) of Gene_expression (production) of interferon gamma in respiratory associated with inflammation, injury, fever and cytokine
12) Confidence 0.38 Published 2005 Journal Am J Ther Section Abstract Doc Link 15891270 Disease Relevance 1.21 Pain Relevance 0.46
Also, increased expression of IFN-gamma was associated with a significant increase in expression of RANTES and monocyte chemotactic protein (MCP)-1, chemokines that may inhibit HIV-1 infection by blocking viral attachment to CCR2 and CCR5 co-receptors.
Positive_regulation (increased) of Gene_expression (expression) of IFN-gamma in monocyte associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
13) Confidence 0.37 Published 2002 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12048358 Disease Relevance 0.87 Pain Relevance 0.77
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Positive_regulation (elevated) of Gene_expression (expression) of interferon gamma in T cells associated with inflammation, infarction and cytokine
14) Confidence 0.30 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.14 Pain Relevance 0.49
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Positive_regulation (up-regulation) of Gene_expression (production) of IFN-gamma in lymphocytes associated with inflammation, cinod and cytokine
15) Confidence 0.28 Published 1995 Journal Cytokine Section Title Doc Link 8589268 Disease Relevance 0.33 Pain Relevance 0.64
When pulsed with the EBNA258-266 peptide, autologous chondrocytes functioned as APCs and, specifically, induced interferon-gamma production in CD8+ T cells.
Positive_regulation (induced) of Gene_expression (production) of interferon-gamma in chondrocytes
16) Confidence 0.27 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19479861 Disease Relevance 0.07 Pain Relevance 0
Further, 2-5A(N6B) significantly enhanced expression of both IFN-alpha and IFN-gamma.
Positive_regulation (enhanced) of Gene_expression (expression) of IFN-gamma
17) Confidence 0.27 Published 2002 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12048358 Disease Relevance 0.87 Pain Relevance 0.78
T cell proliferation and IFN-gamma production were induced from highly purified T cells by stimulation with immobilized mAb to CD3.
Positive_regulation (induced) of Gene_expression (production) of IFN-gamma in T cells
18) Confidence 0.26 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10598881 Disease Relevance 0.33 Pain Relevance 0.16
The observations of no increase in the levels of plasma IFNG in both patient categories when compared to controls as well as basal gene expression in the lungs of critically ill patients point out lack of co-ordination in the modulation of innate and adaptive immune responses.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of IFNG in lungs associated with critical illness
19) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.82 Pain Relevance 0.31
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Positive_regulation (elevated) of Gene_expression (expression) of IFN-gamma in T cells associated with inflammation, infarction and cytokine
20) Confidence 0.21 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.15 Pain Relevance 0.49

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