INT252296

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 58 92.88 High High
Inflammation 33 92.36 High High
Inflammatory response 1 88.08 High High
cytokine 39 79.96 Quite High
Osteoarthritis 1 70.84 Quite High
psoriasis 37 61.04 Quite High
chemokine 23 50.00 Quite Low
Arthritis 13 22.72 Low Low
aspirin 1 10.80 Low Low
Etanercept 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 58 92.88 High High
Disease 27 92.72 High High
INFLAMMATION 31 92.36 High High
Gingival Overgrowth 1 87.56 High High
Synovitis 12 72.36 Quite High
Osteoarthritis 1 70.84 Quite High
Inflammatory Bowel Disease 5 70.24 Quite High
Mucositis 1 65.20 Quite High
Psoriasis 41 64.64 Quite High
Arthropathy 1 26.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti TNF- however down-regulates the production of IL-1, IL-6, IL-8, and GM-CSF [28,29].
TNF Regulation (regulates) of Gene_expression (production) of IL-1
1) Confidence 0.03 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.49 Pain Relevance 0.14
A synergistic effect on IL-6 production between IL-1, TNF-?
TNF Regulation (effect) of Gene_expression (production) of IL-1
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.79 Pain Relevance 0.35

General Comments

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