INT252304

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 1
T lymphocytes 1
Cd27 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 91.24 High High
Arthritis 20 77.68 Quite High
antagonist 9 62.36 Quite High
rheumatoid arthritis 50 56.80 Quite High
Inflammation 33 50.24 Quite High
Inflammatory response 3 48.00 Quite Low
Osteoarthritis 33 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.44 Very High Very High Very High
Autoimmune Disease 21 90.00 High High
Disease 41 85.32 High High
Hypersensitivity 22 85.00 Quite High
Arthritis 28 77.68 Quite High
Asthma 5 75.44 Quite High
Systemic Lupus Erythematosus 6 70.24 Quite High
Eosinophilia 2 59.72 Quite High
Rheumatoid Arthritis 58 56.80 Quite High
Immunization 7 55.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive expression of CD70 under the control of the CD19 promoter in transgenic mice leads to a persistent stimulation of CD27.
Positive_regulation (stimulation) of CD27 associated with targeted disruption
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.44 Pain Relevance 0.03
And mechanisms of strengthen humoral immunity by promoting CpG-mediated stimulation of CD27(+) B cells via activation of p38MAPK have been suggested [37].
Positive_regulation (stimulation) of CD27 in B cells
2) Confidence 0.29 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.42 Pain Relevance 0.06
In MSC-treated immunized mice, CD4+CD25+CD27+ Tregs were increased significantly compared with non-MSC-treated mice, and Tregs from these mice inhibited proliferation of T lymphocytes when proliferation was recalled using collagen type II.
Positive_regulation (increased) of CD27 in T lymphocytes
3) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.47 Pain Relevance 0.23

General Comments

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