INT252308

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.24
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 6
T-cells 1
DEC-205 1
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 81 93.00 High High
Inflammation 86 92.60 High High
imagery 46 78.92 Quite High
Deep tissue 2 68.92 Quite High
abatacept 2 60.40 Quite High
rheumatoid arthritis 19 56.16 Quite High
Bioavailability 1 35.72 Quite Low
tolerance 9 26.40 Quite Low
Potency 2 19.36 Low Low
Multiple sclerosis 162 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 93 92.60 High High
Candida Infection 137 92.40 High High
Influenza Virus Infection 4 88.32 High High
Infection 65 75.60 Quite High
Systemic Lupus Erythematosus 44 75.48 Quite High
Targeted Disruption 17 74.72 Quite High
Rheumatoid Arthritis 19 56.16 Quite High
Hypersensitivity 29 50.00 Quite Low
Viral Meningitis 3 50.00 Quite Low
Adhesions 19 45.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PMA, which is known to cause B cell activation [36], resulted in the upregulation of CD40, CD86, and CD80 and the downregulation of MHC II.
Positive_regulation (upregulation) of CD80 in CD86
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.07 Pain Relevance 0.11
CD80 levels increased from 13.5% before activation to 18.4%, after activation in control cultures.
Positive_regulation (increased) of CD80
2) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
These results was consistent with the report from Anne Krug that CpG could promote survival of PDCs, activate purified PDCs by a rapid increase of CD80, CD86 and CD40 expression but the increased degree of CD80 was much lower than that of CD86 [37].
Positive_regulation (increase) of CD80 in CD86
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.29 Pain Relevance 0
In contrast, CD80 and CD86 are inducible on DCs and other APCs upon stimulation.
Positive_regulation (inducible) of CD80 in CD86
4) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.11 Pain Relevance 0.12
For FACS analysis, the following monoclonal antibodies were used: I-A/I-E, CD80, CD86, CD11c, and DEC-205.
Positive_regulation (used) of CD80 in DEC-205
5) Confidence 0.22 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 0.40 Pain Relevance 0
The combination of this interaction further drives the upregulation of both CD80 and CD86 on the surface of APCs.
Positive_regulation (upregulation) of CD80 in CD86
6) Confidence 0.19 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0.09
Significant upregulation of CD40, CD80 and CD86 was observed in JEV infected NSPCs at 3 dpi only compared to uninfected controls and JEV infected isotype controls (Fig. 2A i, ii, iii v, vi, vii) (p<0.05).
Positive_regulation (upregulation) of CD80 in CD86
7) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.19 Pain Relevance 0
Zhang et al. [73] reported that MSCs inhibited the upregulation of CD1a, CD40, CD80, and CD86 during DC maturation.
Positive_regulation (upregulation) of CD80 in CD86
8) Confidence 0.09 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.17 Pain Relevance 0.13
Mature DCs (mDC) express high levels of co-stimulatory molecules CD40, CD80 and CD86, which synergize with antigen in the activation of naïve T-cells.
Positive_regulation (levels) of CD80 in T-cells
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0

General Comments

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