INT252316

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
Macrophages 2
CD86 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 89.88 High High
Potency 1 85.08 High High
cytokine 17 76.64 Quite High
Inflammation 13 46.80 Quite Low
cva 2 43.96 Quite Low
Neuritis 24 5.00 Very Low Very Low Very Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 75.20 Quite High
Disease 19 68.44 Quite High
Autoimmune Disease 22 66.44 Quite High
Syndrome 19 50.00 Quite Low
Disorder Of Lipid Metabolism 6 50.00 Quite Low
INFLAMMATION 14 46.80 Quite Low
Cv General 3 Under Development 2 43.96 Quite Low
Thrombosis 1 33.88 Quite Low
Systemic Lupus Erythematosus 6 26.16 Quite Low
Experimental Autoimmune Neuritis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophages of apoE-deficient mice stimulated by exogenous antigen are more effective in the upregulating of main histocompatibility complex (MHC) class II molecules and costimulatory molecules like CD40 and CD80, with increased IFN-?
Regulation (effective) of Regulation (upregulating) of CD40 in Macrophages
1) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.37 Pain Relevance 0.07
Ligands for ICOS are constitutively expressed on APCs and, in contrast to CD80 and CD86, do not underlie the control of CD40 or signals involving the NF-?
Neg (not) Regulation (underlie) of Regulation (control) of CD40 in CD86
2) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.34 Pain Relevance 0.08

General Comments

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