INT252317

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
CD86 2
cornea 2
Cd28 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 77.28 Quite High
antagonist 1 75.64 Quite High
abatacept 4 67.68 Quite High
rheumatoid arthritis 18 63.44 Quite High
corticosteroid 1 37.60 Quite Low
cINOD 1 36.64 Quite Low
Inflammation 20 32.56 Quite Low
tolerance 3 23.04 Low Low
Kinase C 6 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 39 99.20 Very High Very High Very High
Cold Sores 53 98.80 Very High Very High Very High
Vesicular Stomatitis 1 88.08 High High
Lymphocytic Choriomeningitis 1 86.56 High High
Autoimmune Disease 24 70.64 Quite High
Keratitis 37 64.48 Quite High
Rheumatoid Arthritis 18 63.44 Quite High
Apoptosis 5 51.40 Quite High
Herpes Simplex Virus Infection 3 50.00 Quite Low
General Immunology 2 36.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The best way to inhibit CD28-CD80/CD86 interaction is by means of cytotoxic T-lymphocyte antigen (CTLA)4-immunoglobulin (Ig).
Negative_regulation (inhibit) of CD28 Binding (interaction) of in CD86
1) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.13 Pain Relevance 0.13
Systemic blockade of B7/CD28 costimulatory interactions using fusion protein CTLA4Ig minimizes the immunoinflammatory lesions caused by HSV infection of the cornea [8,9].
Negative_regulation (blockade) of CD28 Binding (interactions) of in cornea associated with cold sores and infection
2) Confidence 0.31 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.84 Pain Relevance 0
mAbs abrogated the effect of CD28 engagement.
Negative_regulation (abrogated) of CD28 Binding (engagement) of
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.12 Pain Relevance 0.08

General Comments

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