INT252325

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.81
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Ahi1) cytoskeleton (Ahi1) cilium (Ahi1)
cytoplasm (Ahi1)
Anatomy Link Frequency
T cells 2
Ahi1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 100.00 Very High Very High Very High
Inflammation 72 99.30 Very High Very High Very High
Endocannabinoid 16 98.40 Very High Very High Very High
Central nervous system 10 93.32 High High
Multiple sclerosis 52 92.56 High High
ischemia 26 92.16 High High
Inflammatory response 9 76.56 Quite High
Potency 2 74.20 Quite High
Cannabinoid 34 70.48 Quite High
Demyelination 3 61.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 99.30 Very High Very High Very High
Cyst 12 97.56 Very High Very High Very High
Injury 165 97.12 Very High Very High Very High
Neurocysticercosis 8 94.48 High High
Convulsion 5 94.20 High High
Targeted Disruption 57 93.04 High High
Multiple Sclerosis 64 92.56 High High
Cv Unclassified Under Development 27 92.16 High High
Disease Progression 1 90.36 High High
Infection 12 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Gene_expression (production) of helper 1 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
1) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.84 Pain Relevance 0.80
CD4 T cells can functionally differentiate into either a T helper 1 (IFN-gamma producing) or the counterbalancing T helper 2 (IL-4 producing) phenotype.
Gene_expression (producing) of helper 1 in T cells
2) Confidence 0.02 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.71 Pain Relevance 0.19
The granulomatous response is associated with production of several cytokines including T helper 1 (Th1) cytokines such as interferon gamma (IFN-?)
Gene_expression (production) of helper 1 associated with cytokine
3) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.67 Pain Relevance 0.27
In vitro, ICOS stimulation augments the production of various T-helper-1 and T-helper-2 cytokines, but does not contribute to clonal expansion.
Gene_expression (production) of T-helper-1 associated with cytokine
4) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.59 Pain Relevance 0.09

General Comments

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