INT252339

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) enzyme binding (Cd40) ligase activity (Mthfd1)
cytoplasm (Mthfd1) extracellular space (Cd40) extracellular region (Cd40)
Anatomy Link Frequency
T cells 2
Cd40 (Mus musculus)
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 74.80 Quite High
Necrosis 2 58.32 Quite High
Cancer 3 57.96 Quite High
Hypersensitivity 1 34.32 Quite Low
Immunodeficiency 1 24.92 Low Low
Autoimmune Disease 15 16.48 Low Low
Rheumatoid Arthritis 14 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One important amplification loop is the stimulation of CD40 on DCs by CD40 ligand expressed on activated CD4 T cells, which upregulates CD80/CD86 expression [22].
CD40 Binding (ligand) of in T cells Positive_regulation (stimulation) of DCs
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.19 Pain Relevance 0

General Comments

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