INT252341

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
CD86 2
Cd40 (Mus musculus)
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 2 46.00 Quite Low
rheumatoid arthritis 14 44.92 Quite Low
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Encephalitis 2 51.32 Quite High
Systemic Lupus Erythematosus 6 51.12 Quite High
Autoimmune Disease 15 49.56 Quite Low
Cv General 3 Under Development 2 46.00 Quite Low
Rheumatoid Arthritis 14 44.92 Quite Low
Thrombosis 1 36.88 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initial suboptimal stimulation of CD4+ T cells induces CD154 to engage CD40 on DCs, which then upregulates the expression of CD80 and CD86, facilitating further co-stimulation through CD28.
CD40 Positive_regulation (upregulates) of Gene_expression (expression) of CD80 in CD86
1) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.10 Pain Relevance 0

General Comments

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