INT252344

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) enzyme binding (Cd40) ligase activity (Mthfd1)
cytoplasm (Mthfd1) extracellular space (Cd40) extracellular region (Cd40)
Anatomy Link Frequency
CD86 1
Cd40 (Mus musculus)
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 34 98.24 Very High Very High Very High
cytokine 14 68.72 Quite High
tolerance 11 50.00 Quite Low
rheumatoid arthritis 27 45.20 Quite Low
cva 4 42.24 Quite Low
Kinase C 6 5.00 Very Low Very Low Very Low
abatacept 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 20 98.24 Very High Very High Very High
Disease Progression 2 97.96 Very High Very High Very High
Targeted Disruption 5 90.72 High High
Encephalitis 2 51.60 Quite High
Autoimmune Disease 22 49.84 Quite Low
Systemic Lupus Erythematosus 6 47.36 Quite Low
Rheumatoid Arthritis 27 45.20 Quite Low
Cv General 3 Under Development 4 42.24 Quite Low
Thrombosis 1 33.12 Quite Low
Disease 31 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we sought to develop inhibitory DCs through gene silencing of CD40.
CD40 Binding (silencing) of DCs
1) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.29 Pain Relevance 0.08
Initial suboptimal stimulation of CD4+ T cells induces CD154 to engage CD40 on DCs, which then upregulates the expression of CD80 and CD86, facilitating further co-stimulation through CD28.
CD40 Binding (engage) of DCs in CD86
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox