INT252356

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (THBS1, Cd47) extracellular space (THBS1) extracellular region (THBS1)
structural molecule activity (THBS1) plasma membrane (Cd47)
Anatomy Link Frequency
fibroblasts 1
THBS1 (Homo sapiens)
Cd47 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 96.44 Very High Very High Very High
Kinase C 12 90.92 High High
rheumatoid arthritis 28 62.16 Quite High
psoriasis 2 48.84 Quite Low
Inflammation 2 45.12 Quite Low
chemokine 2 26.96 Quite Low
tolerance 6 5.00 Very Low Very Low Very Low
abatacept 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Synovitis 2 98.60 Very High Very High Very High
Stress 2 72.16 Quite High
Rheumatoid Arthritis 28 62.16 Quite High
Psoriasis 2 48.84 Quite Low
Disease 24 45.48 Quite Low
INFLAMMATION 2 45.12 Quite Low
Autoimmune Disease 30 8.72 Low Low
Systemic Lupus Erythematosus 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the classical SIRP (signal regulatory protein) ligands, CD47 binds to thrombospondin, which is highly expressed in the synovial environment, in particular in diffuse synovitis that is poorly vascularized [84].
thrombospondin Binding (binds) of CD47 associated with synovitis
1) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.20 Pain Relevance 0.12
CD47 and thrombospondin can form a trimolecular complex with CD36 expressed on synovial fibroblasts.
thrombospondin Binding (complex) of CD47 in fibroblasts
2) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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