INT25236

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.69
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (REG1A)
Anatomy Link Frequency
PSP 2
whiskers 1
motor neuron 1
neutrophils 1
REG1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 97.58 Very High Very High Very High
Multiple sclerosis 5 96.40 Very High Very High Very High
headache 2 89.32 High High
addiction 8 86.52 High High
spinal inflammation 3 80.64 Quite High
depression 13 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 148 100.00 Very High Very High Very High
Paresis 9 100.00 Very High Very High Very High
Motor Neuron Diseases 4 99.22 Very High Very High Very High
Myasthenia Gravis 3 98.56 Very High Very High Very High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 6 98.04 Very High Very High Very High
Spinal Cord Diseases 5 97.00 Very High Very High Very High
Demyelinating Disease 4 96.40 Very High Very High Very High
Headache 2 89.32 High High
Ankylosing Spondylitis 3 80.64 Quite High
Polymyositis 1 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In three other families a complete association of BoLA-A8 and PSP was observed.
PSP Binding (association) of in PSP associated with paresis
1) Confidence 0.47 Published 1993 Journal Anim. Genet. Section Abstract Doc Link 8498713 Disease Relevance 0.95 Pain Relevance 0.27
Furthermore, binding of fluorescein isothiocyanate-labeled recombinant PSP/reg to human neutrophils was demonstrated.
reg Binding (binding) of in neutrophils
2) Confidence 0.47 Published 2009 Journal Crit. Care Med. Section Body Doc Link 19325491 Disease Relevance 0.12 Pain Relevance 0
Furthermore, PSP/reg binds to and activates neutrophils.
reg Binding (binds) of in PSP
3) Confidence 0.47 Published 2009 Journal Crit. Care Med. Section Body Doc Link 19325491 Disease Relevance 0 Pain Relevance 0
Twelve patients (5 with multiple sclerosis, 1 with chronic progressive myelopathy, 2 with chronic inflammatory polyradiculoneuropathy, 2 with myasthenia gravis, and 2 with motor neuron disease) had low-titer HTLV-I antibodies that reacted with a single gag protein, p19 or p24, on Western blot assay.
p19 Binding (reacted) of in motor neuron associated with spinal cord diseases, multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy, inflammation, myasthenia gravis and motor neuron diseases
4) Confidence 0.36 Published 1989 Journal Ann. Neurol. Section Abstract Doc Link 2510585 Disease Relevance 2.00 Pain Relevance 0.53
For the élite practitioners associated with cancer agencies like the ICRF and the BECC, a charitable organisation founded in 1923 for the purpose of promoting clinical research, the main question was whether cancer control should take priority over research.
ICRF Binding (associated) of associated with cancer
5) Confidence 0.32 Published 2010 Journal Social History of Medicine Section Body Doc Link PMC2911267 Disease Relevance 0.61 Pain Relevance 0
The disparity between studies could be due to different reasons: 1) different amplitude of sensory evoked potentials (see Fig. 8C); 2) stimulating one whisker versus several whiskers, 3) averaging PSPs that trigger an up state together with those occurring during down states and comparing them with PSPs in up states, 4) different cortical areas, species, or specific synaptic connections that behave differently [40], [41].
PSPs Binding (comparing) of in whiskers
6) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0 Pain Relevance 0.11

General Comments

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