INT252367

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CTLA4) nucleolus (RUNX1) plasma membrane (CTLA4)
nucleus (RUNX1) DNA binding (RUNX1) transcription factor binding (RUNX1)
RUNX1 (Homo sapiens)
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 123 92.52 High High
rheumatoid arthritis 42 90.80 High High
Arthritis 3 49.20 Quite Low
cytokine 2 32.64 Quite Low
Inflammation 1 14.64 Low Low
methotrexate 28 5.00 Very Low Very Low Very Low
Infliximab 18 5.00 Very Low Very Low Very Low
Etanercept 10 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 42 90.80 High High
Organ Transplantation 1 71.20 Quite High
Disease Progression 1 64.64 Quite High
Autoimmune Disease 6 58.72 Quite High
Systemic Lupus Erythematosus 2 56.32 Quite High
Renal Disease 2 55.52 Quite High
Arthritis 3 49.20 Quite Low
Immunization 1 45.36 Quite Low
Disease 21 39.12 Quite Low
Necrosis 3 34.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like native CTLA4, the fusion protein binds more avidly to CD80/86 than to CD28.
fusion protein Binding (binds) of CTLA4
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.48 Pain Relevance 0.18

General Comments

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