INT25237

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Context Info
Confidence 0.29
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.58
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (NRSN1)
Anatomy Link Frequency
T lymphocytes 2
motor neuron 1
NRSN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 97.58 Very High Very High Very High
Multiple sclerosis 5 96.96 Very High Very High Very High
headache 4 89.32 High High
cytokine 16 5.00 Very Low Very Low Very Low
iatrogenic 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 4 99.22 Very High Very High Very High
Myasthenia Gravis 3 98.56 Very High Very High Very High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 6 98.04 Very High Very High Very High
Spinal Cord Diseases 9 97.00 Very High Very High Very High
Demyelinating Disease 4 96.96 Very High Very High Very High
Cicatrix 24 95.08 Very High Very High Very High
Headache 4 89.32 High High
Polymyositis 1 69.04 Quite High
Neurological Disease 2 63.44 Quite High
Immunization 6 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twelve patients (5 with multiple sclerosis, 1 with chronic progressive myelopathy, 2 with chronic inflammatory polyradiculoneuropathy, 2 with myasthenia gravis, and 2 with motor neuron disease) had low-titer HTLV-I antibodies that reacted with a single gag protein, p19 or p24, on Western blot assay.
p24 Binding (reacted) of in motor neuron associated with spinal cord diseases, multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy, inflammation, myasthenia gravis and motor neuron diseases
1) Confidence 0.29 Published 1989 Journal Ann. Neurol. Section Abstract Doc Link 2510585 Disease Relevance 2.00 Pain Relevance 0.53
The CA protein appears to be a major target for the host immune response with high antibody titers found in the sera of infected animals and two defined regions of p24 being recognized by specific T lymphocytes [110,111].
p24 Binding (recognized) of in T lymphocytes
2) Confidence 0.03 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.05 Pain Relevance 0
The CA protein appears to be a major target for the host immune response with high antibody titers found in the sera of infected animals and two defined regions of p24 being recognized by specific T lymphocytes [110,111].
p24 Binding (target) of in T lymphocytes
3) Confidence 0.03 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.05 Pain Relevance 0
Responses to peptides p9, p13, p24 and p28 were most frequently observed (data not shown), consistent with the UK trials [12].


p24 Binding (Responses) of
4) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.47 Pain Relevance 0

General Comments

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