INT252379

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NCF4) cytoplasm (NCF4)
Anatomy Link Frequency
brain 1
nociceptors 1
NCF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 150 99.42 Very High Very High Very High
c fibre 2 96.02 Very High Very High Very High
allodynia 8 95.80 Very High Very High Very High
Spinal cord 6 94.88 High High
Thalamus 2 94.24 High High
wide dynamic range 4 91.66 High High
nociceptor 2 88.70 High High
central sensitization 10 87.96 High High
hyperexcitability 12 84.48 Quite High
medulla 48 72.36 Quite High
Disease Link Frequency Relevance Heat
Headache 156 99.42 Very High Very High Very High
Congenital Anomalies 10 98.96 Very High Very High Very High
Cognitive Disorder 4 97.52 Very High Very High Very High
Neuropathic Pain 8 95.80 Very High Very High Very High
Nociception 18 85.08 High High
Pain 46 65.92 Quite High
Urological Neuroanatomy 14 64.80 Quite High
Hyperalgesia 2 46.20 Quite Low
Migraine Disorders 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, note that while NCF hypofunction was found in migraineurs during their interictal phase, the NCF dysfunction may change or even be supplanted by abnormalities in other brain regions during the different phases of an actual migraine attack.
Spec (may) Regulation (change) of NCF in brain associated with congenital anomalies and migraine
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 1.01 Pain Relevance 1.01
Several possible explanations may account for this: (1) 41°C is known to activate nociceptors, and what we observe may reflect an enhancement of their sensitivity; (2) since NCF sends descending projections to second-order wide dynamic range neurons [29], which encode both non-noxious and noxious stimulus intensities, perhaps NCF also affects innocuous stimulus processing at sub-perceptual levels in the migraine interictal phase; (3) low-threshold C-fiber afferents may convey other information that differentially activate or involve descending modulatory systems [34], including the NCF; (4) corticobulbar input in migraine patients may differentially modulate NCF activity [35] regardless of stimulus intensity via a sensory-cognitive mechanism; (5) the interictal migraine brain may be hyper-excitable in regards to general sensory processing [36], which may or may not include the involvement of NCF.
Regulation (modulate) of NCF in nociceptors associated with c fibre, cognitive disorder, migraine, nociceptor and wide dynamic range
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.72 Pain Relevance 0.82

General Comments

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