INT25238

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.93
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (REG1A)
Anatomy Link Frequency
PSP 2
digestive tract 1
soma 1
REG1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 98.66 Very High Very High Very High
Multiple sclerosis 5 97.22 Very High Very High Very High
headache 2 79.72 Quite High
Chronic pancreatitis 4 79.20 Quite High
addiction 1 66.16 Quite High
Nav1.6 12 5.00 Very Low Very Low Very Low
Nav1.2 9 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 6 99.12 Very High Very High Very High
Spinal Cord Diseases 5 98.00 Very High Very High Very High
Pancreatitis 14 97.60 Very High Very High Very High
Demyelinating Disease 4 97.22 Very High Very High Very High
Motor Neuron Diseases 4 88.84 High High
Myasthenia Gravis 3 87.52 High High
Headache 2 79.72 Quite High
Chronic Progressive Multiple Sclerosis 1 63.12 Quite High
Polymyositis 1 59.44 Quite High
Neurological Disease 2 53.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic stone protein (PSP/reg), which shows strong sequence homology to PAP, is secreted into pancreatic juice under physiologic and pathologic conditions.
Localization (secreted) of PSP in PSP
1) Confidence 0.78 Published 2001 Journal Pancreas Section Abstract Doc Link 11249074 Disease Relevance 0.42 Pain Relevance 0.07
In 4 (2 with multiple sclerosis, 1 with chronic progressive myelopathy, and 1 with chronic inflammatory polyradiculoneuropathy) of these 12, the antibodies that were all directed to p19 were determined to be specific by homologous competitive inhibition.
Localization (directed) of p19 associated with spinal cord diseases, multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy and inflammation
2) Confidence 0.73 Published 1989 Journal Ann. Neurol. Section Abstract Doc Link 2510585 Disease Relevance 2.02 Pain Relevance 0.57
Immunocytochemical localization of pancreatic stone protein in the human digestive tract.
Localization (localization) of pancreatic stone protein in digestive tract
3) Confidence 0.69 Published 1986 Journal Pancreas Section Title Doc Link 3550781 Disease Relevance 0.08 Pain Relevance 0.08
Pancreatic stone protein (PSP/reg), which shows strong sequence homology to PAP, is secreted into pancreatic juice under physiologic and pathologic conditions.
Localization (secreted) of reg in PSP
4) Confidence 0.68 Published 2001 Journal Pancreas Section Abstract Doc Link 11249074 Disease Relevance 0.42 Pain Relevance 0.07
We further quantified the electrotonic isolation by estimating the local space constant across the dendritic tree (see Methods), and found that the space constant of most dendritic loci was less than the distance to soma (Figure 2e), consistent with spatially localized PSPs.
Localization (localized) of PSPs in soma
5) Confidence 0.41 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0 Pain Relevance 0.03

General Comments

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