INT252389

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.78
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 225 98.76 Very High Very High Very High
Osteoarthritis 81 93.40 High High
antagonist 24 87.92 High High
Arthritis 6 28.68 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 225 100.00 Very High Very High Very High
Rheumatoid Arthritis 225 98.76 Very High Very High Very High
Osteoarthritis 81 93.40 High High
Paralysis 3 67.52 Quite High
Seronegative Spondarthritis 3 28.68 Quite Low
Cancer 9 18.48 Low Low
Arthritis 3 9.76 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adhesion-enhancing effect of adrenomedullin is mediated by the adrenomedullin receptor CLR/RAMP
Negative_regulation (effect) of Gene_expression (adhesion-enhancing) of adrenomedullin associated with adhesions
1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.94 Pain Relevance 0.60
The adhesion-enhancing effect of adrenomedullin is mediated by the adrenomedullin receptor CLR/RAMP
Negative_regulation (receptor) of Gene_expression (/) of adrenomedullin associated with adhesions
2) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.92 Pain Relevance 0.60
As siRNA would inhibit not only adrenomedullin-stimulated adhesion, but also basal adhesion, we chose talin IP followed by integrin ?
Negative_regulation (inhibit) of Gene_expression (adhesion) of adrenomedullin-stimulated associated with adhesions
3) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.84 Pain Relevance 0.10
Directly following this, our null hypothesis is that the AM dynamics could be described in areas 17 and 18 byin which, ?
Negative_regulation (described) of Gene_expression (dynamics) of AM
4) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0.07 Pain Relevance 0

General Comments

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