INT25240

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Context Info
Confidence 0.43
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.10
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pcbd1) nucleolus (Pcbd1) nucleus (Pcbd1)
molecular_function (Pcbd1) cellular_component (Pcbd1) biological_process (Pcbd1)
Anatomy Link Frequency
hepatocyte 2
neuronal 1
colon 1
Pcbd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 4 99.98 Very High Very High Very High
cINOD 21 98.90 Very High Very High Very High
cva 1 89.92 High High
cytokine 3 89.16 High High
agonist 69 87.92 High High
Nerve growth factor 3 52.76 Quite High
Analgesic 2 28.04 Quite Low
epidural 15 25.36 Quite Low
analgesia 9 15.64 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 99.82 Very High Very High Very High
Apoptosis 34 99.32 Very High Very High Very High
Disease 4 97.52 Very High Very High Very High
Alzheimer's Dementia 3 93.92 High High
Stress 9 90.84 High High
Cv General 3 Under Development 1 89.92 High High
Hemorrhage 1 88.76 High High
Infection 3 88.36 High High
Abscess 1 84.36 Quite High
Injury 3 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another set of data indicates that NSAIDs may induce apoptosis and prevent colon cancer without inhibiting the activity of PHS.
Negative_regulation (inhibiting) of PHS in colon associated with colon cancer, cinod and apoptosis
1) Confidence 0.43 Published 1999 Journal Apoptosis Section Abstract Doc Link 14634340 Disease Relevance 0.68 Pain Relevance 0.41
NSAIDs are pleiotropic in their biochemical activities; their best known effect is inhibition of prostaglandin H synthase (PHS), the enzyme catalyzing the biosynthesis of prostaglandins.
Negative_regulation (inhibition) of PHS associated with cinod
2) Confidence 0.43 Published 1999 Journal Apoptosis Section Abstract Doc Link 14634340 Disease Relevance 0.63 Pain Relevance 0.41
The mechanism of inhibition of prostaglandin H synthase (PHS) by eugenol was investigated using purified apoenzyme reconstituted with either manganese protoporphyrin IX (Mn-PHS) or hematin (Fe-PHS).
Negative_regulation (inhibition) of PHS
3) Confidence 0.38 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2511429 Disease Relevance 0 Pain Relevance 0
Other phenolic compounds, including guaiacol, butylated hydroxyanisole, and acetaminophen inhibited Mn-PHS in a manner similar to eugenol.
Negative_regulation (inhibited) of Mn-PHS associated with paracetamol
4) Confidence 0.25 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2511429 Disease Relevance 0 Pain Relevance 0.10
Higher concentrations of eugenol were required to inhibit Fe-PHS than Mn-PHS (which retains cyclooxygenase activity but not peroxidase activity).
Negative_regulation (inhibit) of Fe-PHS
5) Confidence 0.25 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2511429 Disease Relevance 0 Pain Relevance 0.05
Chromatographic analysis of the metabolism of 14C-labeled arachidonic acid in this system revealed that PB-dependent inactivation of PHS is markedly increased in the presence of 100 microM H2O2.
Negative_regulation (inactivation) of PHS
6) Confidence 0.13 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 3917545 Disease Relevance 0.08 Pain Relevance 0.08
As PB undergoes peroxide-dependent co-oxygenation catalyzed by PHS, we propose that it is an oxygenated derivative of PB, rather than the parent compound, which is responsible for the inactivation of PHS and prostacyclin synthase.
Negative_regulation (inactivation) of PHS
7) Confidence 0.13 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 3917545 Disease Relevance 0 Pain Relevance 0
To detect a reduction in PHS of 3 days (SD 5 days), which is in agreement with the study of Lobo et al. [17], with a two-sided 5% significance level and a power of 80%, a sample size of 50 patients per group was necessary, given an anticipated dropout rate of 10%.
Negative_regulation (reduction) of PHS
8) Confidence 0.06 Published 2009 Journal Trials Section Body Doc Link PMC2717956 Disease Relevance 1.11 Pain Relevance 0.04
activation was shown to suppress both spontaneous rat hepatocyte PCD and the PCD induced by transforming growth factor-?
Negative_regulation (suppress) of PCD in hepatocyte
9) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.19 Pain Relevance 0.24
During growth factor deprivation induced PCD in neuronal PC12 cells, there is a sustained activation of the JNK and p38 pathways while the activities of ERK pathway is inhibited.
Negative_regulation (deprivation) of PCD in neuronal
10) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.21 Pain Relevance 0.03
activation was shown to suppress both spontaneous rat hepatocyte PCD and the PCD induced by transforming growth factor-?
Negative_regulation (suppress) of PCD in hepatocyte
11) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.19 Pain Relevance 0.24

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