INT25241

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Context Info
Confidence 0.56
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.97
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
liver 2
brain 2
cardiac myocytes 1
sublingual 1
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 12 99.82 Very High Very High Very High
agonist 2 97.20 Very High Very High Very High
Endogenous opioid 4 96.40 Very High Very High Very High
Angina 4 88.28 High High
ischemia 2 85.52 High High
opioid receptor 2 72.48 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 10 99.80 Very High Very High Very High
Contracture 4 99.36 Very High Very High Very High
Diabetes Mellitus 16 98.44 Very High Very High Very High
Cv General 3 Under Development 4 88.28 High High
Reperfusion Injury 2 75.00 Quite High
Congenital Anomalies 2 72.40 Quite High
Hypoxia 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the CAD-patients decrease of sigma R was shown after sublingual GTN: 19.5 +/- 26.4 mm (p less than 0.05).
Negative_regulation (decrease) of sigma R in sublingual associated with coronary artery disease
1) Confidence 0.56 Published 1989 Journal Z Kardiol Section Abstract Doc Link 2511682 Disease Relevance 0.44 Pain Relevance 0.12
After bypass operation the decrease of sigma R under glycerol trinitrate practically disappeared.
Negative_regulation (decrease) of sigma R
2) Confidence 0.56 Published 1985 Journal Z Gesamte Inn Med Section Abstract Doc Link 3931363 Disease Relevance 0.15 Pain Relevance 0.08
In the coronary patients after glycerol trinitrate a decrease of sigma R was shown.
Negative_regulation (decrease) of sigma R
3) Confidence 0.56 Published 1985 Journal Z Gesamte Inn Med Section Abstract Doc Link 3931363 Disease Relevance 0.16 Pain Relevance 0.08
After bypass surgery the decrease of sigma R after glycerol trinitrate could no longer be shown.
Negative_regulation (decrease) of sigma R
4) Confidence 0.41 Published 1989 Journal Z Kardiol Section Abstract Doc Link 2511682 Disease Relevance 0.40 Pain Relevance 0.12
Scatchard analysis revealed a 27% (p<0.01) decreased in sigma-1 receptor density and a 33% (p<0.01) decreased in sigma-2 receptor density in whole brain of 10-week STZ-diabetic rats.
Negative_regulation (decreased) of sigma-1 receptor in brain associated with diabetes mellitus
5) Confidence 0.40 Published 1999 Journal Life Sci. Section Abstract Doc Link 10622239 Disease Relevance 0.63 Pain Relevance 0.18
Scatchard analysis revealed a 27% (p<0.01) decreased in sigma-1 receptor density and a 33% (p<0.01) decreased in sigma-2 receptor density in whole brain of 10-week STZ-diabetic rats.
Negative_regulation (decreased) of sigma-2 receptor in brain associated with diabetes mellitus
6) Confidence 0.40 Published 1999 Journal Life Sci. Section Abstract Doc Link 10622239 Disease Relevance 0.65 Pain Relevance 0.18
The sigma-receptor blocking contributes to a decrease in postischemic contracture and preservation of the cardiac cell membrane integrity.
Negative_regulation (decrease) of sigma-receptor associated with contracture
7) Confidence 0.40 Published 1998 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 9785415 Disease Relevance 0.26 Pain Relevance 0.22
In sigma-receptor blockade, reoxygenation contracture does not appear.
Negative_regulation (blockade) of sigma-receptor associated with contracture
8) Confidence 0.40 Published 1998 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 9785415 Disease Relevance 0.27 Pain Relevance 0.21
Apparent desensitization of a sigma receptor sub-population in neonatal rat cardiac myocytes by pre-treatment with sigma receptor ligands.
Negative_regulation (desensitization) of sigma receptor in cardiac myocytes associated with fortral
9) Confidence 0.37 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8720595 Disease Relevance 0 Pain Relevance 0.18
In addition, we have synthesized a carrier-free, radioiodinated fenpropimorph-like photoaffinity label, 1-N-(2',6'-dimethyl-morpholino)-3-(4-azido-3-[(125)I]iodo-phenyl)propane ([(125)I]IAF), which covalently derivatized the sigma-1 receptor (25.3 kDa) in both the rat liver and guinea pig liver membranes and the sigma-2 receptor (18 kDa) in rat liver membranes with high specificity.
Negative_regulation (derivatized) of sigma-1 receptor in liver
10) Confidence 0.33 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17622576 Disease Relevance 0 Pain Relevance 0.04
In addition, we have synthesized a carrier-free, radioiodinated fenpropimorph-like photoaffinity label, 1-N-(2',6'-dimethyl-morpholino)-3-(4-azido-3-[(125)I]iodo-phenyl)propane ([(125)I]IAF), which covalently derivatized the sigma-1 receptor (25.3 kDa) in both the rat liver and guinea pig liver membranes and the sigma-2 receptor (18 kDa) in rat liver membranes with high specificity.
Negative_regulation (derivatized) of sigma-2 receptor in liver
11) Confidence 0.33 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17622576 Disease Relevance 0 Pain Relevance 0.09

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