INT252417

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry12) mitochondrion (P2ry12) plasma membrane (P2ry12)
signal transducer activity (P2ry12)
Anatomy Link Frequency
microglia 1
P2ry12 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 3 99.78 Very High Very High Very High
Lasting pain 3 98.64 Very High Very High Very High
Migraine 1 93.32 High High
Neuropathic pain 1 93.04 High High
Pain 4 92.64 High High
antagonist 7 75.16 Quite High
opioid receptor 5 74.88 Quite High
adenocard 25 68.04 Quite High
Glutamate 20 67.68 Quite High
Action potential 6 57.28 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 99.64 Very High Very High Very High
Disease 4 98.72 Very High Very High Very High
Pain 7 98.20 Very High Very High Very High
Stroke 1 98.04 Very High Very High Very High
Thrombosis 1 97.60 Very High Very High Very High
Nociception 31 96.52 Very High Very High Very High
Nervous System Injury 1 96.04 Very High Very High Very High
Headache 1 93.32 High High
Polycystic Ovary Syndrome 1 72.20 Quite High
Inflammatory Pain 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the powerful actions of spinal microglia in neuropathic pain models, systemic blockade of P2Y12 appears to be protective against persistent pain at the spinal level despite the anti-nociceptive actions of this receptor in primary afferents.
Negative_regulation (blockade) of P2Y12 in microglia associated with nociception, pain, lasting pain and eae
1) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.86 Pain Relevance 0.58
For example, clopidogrel, the P2Y12 inhibitor, the first of such drugs, is already in use for stroke and thrombosis [5] and, it is hoped, will be a forerunner among many.
Negative_regulation (inhibitor) of P2Y12 associated with stroke and thrombosis
2) Confidence 0.19 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.73 Pain Relevance 0.31

General Comments

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