INT25242

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Context Info
Confidence 0.66
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 3.93
Pain Relevance 5.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
liver 2
neuronal 1
tail 1
neurons 1
cerebellum 1
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 15 100.00 Very High Very High Very High
narcan 8 100.00 Very High Very High Very High
Opioid 5 99.84 Very High Very High Very High
tail-flick 9 99.60 Very High Very High Very High
Morphine 24 99.20 Very High Very High Very High
Dynorphin 1 98.08 Very High Very High Very High
antagonist 11 97.98 Very High Very High Very High
Potency 2 97.98 Very High Very High Very High
Enkephalin 2 97.52 Very High Very High Very High
Hippocampus 4 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 1 99.92 Very High Very High Very High
Myocardial Infarction 28 99.54 Very High Very High Very High
Dystonia 1 98.16 Very High Very High Very High
Dyskinesias 1 97.52 Very High Very High Very High
Coronary Artery Disease 5 94.68 High High
Cv General 3 Under Development 2 83.36 Quite High
Urological Neuroanatomy 5 81.32 Quite High
Stress 1 75.76 Quite High
Hypoxia 5 73.72 Quite High
Hypoglycemia 3 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The control group revealed a slight increase of sigma R.
Positive_regulation (increase) of sigma R
1) Confidence 0.66 Published 1985 Journal Z Gesamte Inn Med Section Abstract Doc Link 3931363 Disease Relevance 0.16 Pain Relevance 0.08
Preincubation of neurons with the irreversible sigma receptor antagonist metaphit blocked DTG-induced inhibition of K(+) channels, confirming that the effect is mediated by sigma receptor activation.
Positive_regulation (activation) of sigma receptor in neurons associated with antagonist
2) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15764734 Disease Relevance 0 Pain Relevance 0.34
The inhibition of K(+) channels by sigma ligands was dose-dependent, and the rank order potency of (+)-pentazocine > ibogaine > 1,3-di-O-tolyguanidin (DTG) suggests that the effect is mediated by sigma-1 receptor activation.
Positive_regulation (activation) of sigma-1 receptor associated with fortral and potency
3) Confidence 0.47 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15764734 Disease Relevance 0 Pain Relevance 0.35
Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures.
Positive_regulation (Activation) of sigma1 receptor in neuronal associated with fortral
4) Confidence 0.46 Published 1998 Journal Neurochem. Int. Section Title Doc Link 9596556 Disease Relevance 0.70 Pain Relevance 0.29
Since (+)-morphine, (-)-morphine and (+)-naloxone do not have any affinity for the naloxone-inaccessible sigma receptors, we therefore propose that (+)-morphine and (-)-morphine attenuate the (-)-morphine-produced tail-flick inhibition via the activation of the naloxone-sensitive sigma receptor originally proposed by Tsao and Su [Tsao, L.T., Su, T.P., 1997.
Positive_regulation (activation) of sigma receptor in tail associated with tail-flick, narcan and morphine
5) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17597599 Disease Relevance 0.23 Pain Relevance 2.16
The control group showed a slight increase of sigma R: 18.7 +/- 16.2 mm (p less than 0.05).
Positive_regulation (increase) of sigma R
6) Confidence 0.45 Published 1989 Journal Z Kardiol Section Abstract Doc Link 2511682 Disease Relevance 0.42 Pain Relevance 0.12
Both ligands produced a significant increase in vacuous chewing movements, suggesting that studies on the consequences of sigma receptor activation may have relevance to animal models of human dystonia and/or dyskinesia.
Positive_regulation (activation) of sigma receptor associated with dystonia and dyskinesias
7) Confidence 0.41 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8453980 Disease Relevance 0.20 Pain Relevance 0.32
In addition, we have synthesized a carrier-free, radioiodinated fenpropimorph-like photoaffinity label, 1-N-(2',6'-dimethyl-morpholino)-3-(4-azido-3-[(125)I]iodo-phenyl)propane ([(125)I]IAF), which covalently derivatized the sigma-1 receptor (25.3 kDa) in both the rat liver and guinea pig liver membranes and the sigma-2 receptor (18 kDa) in rat liver membranes with high specificity.
Positive_regulation (derivatized) of sigma-1 receptor in liver
8) Confidence 0.38 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17622576 Disease Relevance 0 Pain Relevance 0.04
In addition, we have synthesized a carrier-free, radioiodinated fenpropimorph-like photoaffinity label, 1-N-(2',6'-dimethyl-morpholino)-3-(4-azido-3-[(125)I]iodo-phenyl)propane ([(125)I]IAF), which covalently derivatized the sigma-1 receptor (25.3 kDa) in both the rat liver and guinea pig liver membranes and the sigma-2 receptor (18 kDa) in rat liver membranes with high specificity.
Positive_regulation (derivatized) of sigma-2 receptor in liver
9) Confidence 0.38 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17622576 Disease Relevance 0 Pain Relevance 0.09
Since no significant effects by sigma-receptor ligands on NPY-induced G-protein activation were observed, we did not see an inverse agonism of NPY and sigma-receptor ligands at the putative NPY/sigma receptor measured at the level of G-protein activation, suggesting that sigma receptors and NPY receptors do not represent a common population in rat hippocampus and cerebellum.
Positive_regulation (activation) of sigma receptor in cerebellum associated with hippocampus
10) Confidence 0.25 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.24
Our findings are consistent with the potential role of NPY as an endogenous ligand for a subtype of sigma receptor with characteristics different from Y1, Y2 and Y3 receptors but sensitive to PYX-1.
Positive_regulation (subtype) of sigma receptor
11) Confidence 0.11 Published 1997 Journal Brain Res. Section Abstract Doc Link 9237537 Disease Relevance 0 Pain Relevance 0.63
Since no significant effects by sigma-receptor ligands on NPY-induced G-protein activation were observed, we did not see an inverse agonism of NPY and sigma-receptor ligands at the putative NPY/sigma receptor measured at the level of G-protein activation, suggesting that sigma receptors and NPY receptors do not represent a common population in rat hippocampus and cerebellum.
Positive_regulation (activation) of sigma receptor in hippocampus associated with hippocampus
12) Confidence 0.08 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.24
OPRs are typical Gi/Go-coupled receptors and activated by opioid peptides derived from the endorphin, dynorphin and enkephalin families, whereas beta-AR stimulated by catecholamines is the model system for Gs-coupled receptors.
Positive_regulation (activated) of OPRs associated with dynorphin, catecholamine, enkephalin and opioid
13) Confidence 0.08 Published 2004 Journal Cardiovasc. Res. Section Abstract Doc Link 15276466 Disease Relevance 0.18 Pain Relevance 0.55
The increased numbers of both sigma1 and sigma2 receptor subtypes in the aged rats compensate for the lowered affinity, and rather enhanced the radioligand-receptor binding.
Positive_regulation (increased) of sigma2 receptor
14) Confidence 0.06 Published 2003 Journal Ann Nucl Med Section Abstract Doc Link 12691135 Disease Relevance 0 Pain Relevance 0.20
The chronometric variation of sigma ST, sigma Q and sigma R were significant in the patients with AMI; this also applied to sigma ST in the control group, but not to sigma Q and sigma R.
Positive_regulation (variation) of sigma R associated with myocardial infarction
15) Confidence 0.04 Published 1980 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 7414254 Disease Relevance 0.55 Pain Relevance 0
The investigation demonstrated that there was a significant inter-individual variation of sigma ST, sigma Q and sigma R in both patient groups.
Positive_regulation (variation) of sigma R
16) Confidence 0.04 Published 1980 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 7414254 Disease Relevance 0.50 Pain Relevance 0
In cases of AMI, the intra-individual variation of sigma St, sigma Q and sigma R was significantly greater than the variation in the error-of-measurement; this applied also to the control group, except for sigma ST which was of the same magnitude.
Positive_regulation (variation) of sigma R associated with myocardial infarction
17) Confidence 0.04 Published 1980 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 7414254 Disease Relevance 0.55 Pain Relevance 0
The variability, chronometric changes and the error-of-measurement when measuring sigma ST, sigma Q and sigma R in an ECG-map were evaluated.
Positive_regulation (measuring) of sigma R
18) Confidence 0.04 Published 1980 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 7414254 Disease Relevance 0.45 Pain Relevance 0

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