INT252442

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.30
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RFC1) nucleus (RFC1) intracellular (RFC1)
RFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 156 98.90 Very High Very High Very High
Inflammation 18 96.24 Very High Very High Very High
agonist 132 95.24 Very High Very High Very High
Potency 53 70.76 Quite High
Pain 4 53.40 Quite High
Neurotransmitter 2 52.76 Quite High
Central nervous system 3 52.04 Quite High
antagonist 42 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 98.00 Very High Very High Very High
INFLAMMATION 22 96.24 Very High Very High Very High
Pain 4 53.40 Quite High
Increased Venous Pressure Under Development 12 25.40 Quite Low
Obesity 2 19.44 Low Low
Disease 9 5.00 Very Low Very Low Very Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 8 5.00 Very Low Very Low Very Low
Cystic Fibrosis 6 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most of the examined molecules, in fact, preferentially bound to the A1 receptor, with Ki binding values ranging from 2.3 to 30.5 nM.
A1 Binding (bound) of
1) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.27
Under physiological conditions, intracellular adenosine reaches a concentration of 100 nM and thus is able to interact only with the high-affinity A1 and A2A AR subtypes.
A1 Binding (interact) of associated with adenocard
2) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.30 Pain Relevance 0.53
Filters for A1 and A2AAR binding were placed in scintillation vials containing 5 mL of Hydrofluor scintillation buffer and counted using a Perkin Elmer liquid scintillation analyzer (Tri-Carb 2810TR).
A1 Binding (binding) of
3) Confidence 0.02 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2865168 Disease Relevance 0 Pain Relevance 0.03

General Comments

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