INT252443

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.59

nucleoplasm (RFC1) nucleus (RFC1) intracellular (RFC1)

RFC1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 60 98.58 adenocard 71 83.52 Inflammation 9 64.64 cytokine 3 55.36 Potency 26 5.00 antagonist 14 5.00 fibrosis 3 5.00 Pain 2 5.00 Opioid 2 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 64.64 Sepsis 1 61.04 Necrosis 1 55.96 Cancer 2 55.60 Vasculogenic Impotence 1 50.08 Erectile Dysfunction 2 40.08 Alopecia 1 29.16 Diabetes Mellitus 4 24.56 Hypertension 2 24.04 Renal Disease 1 21.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, for the time being, the selectivity profile of new potential A2B AR agonists can only be speculated in view of the ratio of binding parameters (Ki values for A1, A2A, A3 ARs) to functional parameters (EC50 for A2B, Tables 1, 2, 3, 4, 5, and 6).

Regulation (values) of A1 associated with agonist

1) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.35 Pain Relevance 0.59

General Comments

This test has worked.