INT252455

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SLURP1) signal transduction (Adora2b) extracellular region (SLURP1)
cell adhesion (SLURP1) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Adora2b (Mus musculus)
SLURP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 142 98.88 Very High Very High Very High
agonist 120 97.60 Very High Very High Very High
Potency 52 79.72 Quite High
Pain 4 73.28 Quite High
Neurotransmitter 2 72.64 Quite High
Central nervous system 2 71.92 Quite High
Inflammation 18 70.96 Quite High
antagonist 28 70.88 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 4 73.28 Quite High
INFLAMMATION 20 70.96 Quite High
Hypoxia 2 62.00 Quite High
Disease 8 58.24 Quite High
Dyslipidemia /

Combined Dyslipidemia

2 56.88 Quite High
Metabolic Syndrome 4 55.76 Quite High
Diabetes Mellitus 8 53.92 Quite High
Muscle Hypertonia 2 49.04 Quite Low
Increased Venous Pressure Under Development 12 45.28 Quite Low
Hypertension 4 25.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A2B ARs have been generally defined as the “low-affinity ARs,” as their lower affinity for the endogenous ligand, adenosine, and for some typical agonists, such as 5?
A2B Binding (affinity) of ARs associated with adenocard and agonist
1) Confidence 0.02 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.27 Pain Relevance 0.65
The 3-methoxyphenyl derivative 51 and the 4-methoxyphenyl derivative 52 also showed appreciable selectivity for A2B versus A2A ARs (3- and 24-fold, respectively) but reduced selectivity for A2B versus A3 ARs (2.1- and 2.6-fold, respectively) in comparison with the corresponding 3/4-hydroxyphenyl analogues 50 (Ki A2A/EC50 A2B?
A2B Binding (selectivity) of ARs
2) Confidence 0.02 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.27 Pain Relevance 0.16

General Comments

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