INT25248

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Context Info
Confidence 0.30
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.22
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1, CGA) extracellular region (GNRH1, CGA) cell-cell signaling (GNRH1, CGA)
extracellular space (GNRH1) small molecule metabolic process (CGA) cellular nitrogen compound metabolic process (CGA)
Anatomy Link Frequency
pituitary 2
GNRH1 (Homo sapiens)
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 10 99.12 Very High Very High Very High
Pain 1 84.76 Quite High
Endogenous opioid 1 80.40 Quite High
Catecholamine 1 64.08 Quite High
Opioid 1 54.16 Quite High
antagonist 3 53.60 Quite High
tricyclic antidepressant 2 39.84 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypogonadotropic Hypogonadism 14 91.84 High High
Reprotox - General 2 4 89.52 High High
Injury 5 85.60 High High
Pain 1 84.76 Quite High
Virilism 1 82.36 Quite High
Galactorrhea 12 81.20 Quite High
Cancer 5 75.00 Quite High
Rhinitis 1 55.76 Quite High
Male Infertility 18 50.00 Quite Low
Pituitary Cancer 9 48.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All subjects showed normal gonadotrophin and TSH responses to GnRH and TRH, respectively.
GnRH Regulation (responses) of gonadotrophin
1) Confidence 0.30 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2512037 Disease Relevance 0 Pain Relevance 0.24
Bone age was 13 years, the LH and FSH secretory responses to GnRH were minimal (LH: < 0.038-->0.28 mIU/ml; FSH: < 0.063-->0.11 mIU/ml), and basal serum testosterone (< 10 ng/dl) and estradiol (< 10 pg/ml) values were undetectable.
GnRH Regulation (responses) of FSH
2) Confidence 0.18 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8887151 Disease Relevance 0.36 Pain Relevance 0.08
After repeated infusions of GnRH, pituitary gonadotrophin responsiveness to GnRH was restored, whilst naloxone still did not affect gonadotrophin levels.
GnRH Regulation (responsiveness) of gonadotrophin in pituitary associated with narcan
3) Confidence 0.01 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 3925670 Disease Relevance 0.25 Pain Relevance 0.30
Nevertheless, pulsatile GnRH therapy depends on a intact pituitary gonadotropin response to the exogenous GnRH (Chuang and Howards 1998).
GnRH Regulation (response) of gonadotropin in pituitary
4) Confidence 0.00 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.61 Pain Relevance 0

General Comments

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