INT25251

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 7.96
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
neurons 2
striatum 1
hippocampus 1
periventricular nucleus 1
neuronal 1
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 3 100.00 Very High Very High Very High
Hyperalgesia 6 99.90 Very High Very High Very High
spinal dorsal horn 1 99.16 Very High Very High Very High
chemokine 44 98.76 Very High Very High Very High
withdrawal 3 98.68 Very High Very High Very High
Dopamine 153 97.84 Very High Very High Very High
Hippocampus 22 97.56 Very High Very High Very High
anesthesia 10 97.00 Very High Very High Very High
Inflammation 119 96.92 Very High Very High Very High
dexamethasone 28 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Hyperalgesia 6 99.90 Very High Very High Very High
Hypercalcemia 3 99.08 Very High Very High Very High
Stress 131 98.60 Very High Very High Very High
Osteoporosis 3 98.44 Very High Very High Very High
Sleep Disorders 42 98.16 Very High Very High Very High
INFLAMMATION 113 96.92 Very High Very High Very High
Sprains And Strains 165 95.08 Very High Very High Very High
Aids-related Complex 74 94.60 High High
Urological Neuroanatomy 4 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It might also be interesting to investigate the expression of the Jun proteins (c-Jun, JunB and JunD) since they dimerize with Fos family members (cFos, FosB, Fra-1, and Fra-2) to form transcriptionally active complexes [74].
cFos Spec (might) Binding (dimerize) of
1) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.08 Pain Relevance 0
It might also be interesting to investigate the expression of the Jun proteins (c-Jun, JunB and JunD) since they dimerize with Fos family members (cFos, FosB, Fra-1, and Fra-2) to form transcriptionally active complexes [74].
Fos Spec (might) Binding (dimerize) of
2) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.08 Pain Relevance 0
B and c-Fos activity
c-Fos Binding (activity) of
3) Confidence 0.36 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 0.21 Pain Relevance 0.15
The hyperalgesia was associated with increased mRNA expression of acid-sensing ion channel (ASIC) 1a, 1b and 3 in the ipsi-lateral dorsal root ganglions (DRGs) by RT-PCR and c-Fos in the ipsi-lateral spinal dorsal horn by immunohistochemistry.
c-Fos Binding (associated) of in dorsal root ganglions associated with ganglion cysts, hyperalgesia, spinal dorsal horn and asic
4) Confidence 0.36 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.78 Pain Relevance 1.08
Using immunohistochemistry, we localized the transcription factors Nrf2, which regulates expression of antioxidant and detoxification protein, and c-Fos, a marker of neuronal activation.
c-Fos Binding (localized) of in neuronal
5) Confidence 0.36 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.47 Pain Relevance 0.27
By contrast, c-Fos was found widely expressed in both groups and was localized in neurons in regions associated with response to stress, immunomodulation, and fluid homeostasis, including the periaqueductal gray and periventricular nucleus.
c-Fos Binding (found) of in periventricular nucleus associated with stress and central grey
6) Confidence 0.36 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.60 Pain Relevance 0.25
We presume that the presence of c-Fos along with GABAAR labeling in neurons in the SD condition is a reflection of their prolonged activity during continuous waking.
c-Fos Binding (presence) of in neurons associated with sleep disorders
7) Confidence 0.35 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1805759 Disease Relevance 0.35 Pain Relevance 0
B and c-Fos binding activity, as well as sustained ERK1/2 activation in lung tissue.


c-Fos Binding (activity) of in lung
8) Confidence 0.35 Published 2010 Journal Part Fibre Toxicol Section Abstract Doc Link PMC2861012 Disease Relevance 1.45 Pain Relevance 0.31
Components of the transcriptional complex AP-1 (Fos, Fosb) exhibited gene expression pattern A.
Fos Binding (complex) of
9) Confidence 0.32 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.04
, FOS, S100 calcium binding protein A9 [S100A9], etc.) other "later" gene interactions were surprising (Figures 4 and 5).
FOS Binding (interactions) of
10) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.22 Pain Relevance 0.16
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Fos Binding (binding) of in hippocampus associated with hippocampus
11) Confidence 0.30 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.23
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Fos Binding (binding) of
12) Confidence 0.30 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
The following gene products emerged as hubs: Fos, a transcription factor involved in stress response; glucocorticoid receptor (encoded by Nr3c1), involved in stress response and inflammation; RhoA, an important signaling molecule associated with cytoskeletal remodeling; and Cdkn1b, which maintains cell cycle arrest.
Fos Binding (emerged) of associated with stress and inflammation
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.67 Pain Relevance 0.05
Pharmacological studies show that Fos immunoreactivity in the striatum and other key regions of
   the brain is increased following administration of D1 and D2 agonists 58, 66, 69, 109, 126, suggesting Fos may be important as a downstream gene regulated by dopaminergic
   signaling. ?
Fos Binding (immunoreactivity) of in striatum associated with agonist
14) Confidence 0.19 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0 Pain Relevance 0.22
The homodimers or heterodimers of Fos/Jun proteins bind to the AP1 site with different affinities (Nakabeppu et al. 1988).
Fos Binding (bind) of
15) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0.13
These proteins bind to a specific sequence (TGAC/GTCA; known as AP1) of the promoter region of the target genes, by forming a homodimer (Jun/Jun) or heterodimer (Fos/Jun).
Fos Binding (bind) of
16) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.33 Pain Relevance 0.03
EMSA analysis shows that CREB and c-Fos can bind CRE in AtT20 cells, and that the binding ability of these nuclear factors is reduced by the treatment of dexamethasone together with cAMP, implying that negative regulation of the CRH gene is caused by the protein-protein interaction between CREB, c-Fos, or other unknown factors and GR on the CRE site.
Fos Binding (bind) of in AtT20 associated with dexamethasone
17) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.11
Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site.
Fos Binding (associates) of
18) Confidence 0.08 Published 1989 Journal Science Section Abstract Doc Link 2512642 Disease Relevance 0.08 Pain Relevance 0.04
Phosphorylated cyclic AMP response-element binding protein and phosphorylated Elk-1 contribute to c-fos expression by binding to the calcium and cyclic AMP response-element and the serum response element, respectively, in the c-fos promoter.
fos Binding (binding) of
19) Confidence 0.07 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.30
Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site.
Fos Binding (associates) of
20) Confidence 0.06 Published 1989 Journal Science Section Abstract Doc Link 2512642 Disease Relevance 0.08 Pain Relevance 0.04

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