INT252552

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CHEK2) nucleus (CHEK2) cell cycle (CHEK2)
cell division (CHEK2)
CHEK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 24 89.60 High High
Analgesic 2 5.00 Very Low Very Low Very Low
GABA receptor 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dna Repair-deficiency Disorders 2 78.56 Quite High
Freckles 2 76.00 Quite High
Sprains And Strains 30 12.04 Low Low
Stress 14 5.00 Very Low Very Low Very Low
Fungal Infection 6 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Poisoning 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like Chk2 phosphorylation, H2AX phosphorylation was induced by compound 15, but not by compound 13 (Figure 6D).
Neg (not) Positive_regulation (induced) of Phosphorylation (phosphorylation) of Chk2
1) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.15 Pain Relevance 0.04
For cells treated with compound 15, we observed robust phosphorylation of Chk2 with two phospho-specific Chk2 antibodies, indicating the activation of the DNA damage checkpoint.
Positive_regulation (observed) of Phosphorylation (phosphorylation) of Chk2
2) Confidence 0.16 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.10 Pain Relevance 0.03

General Comments

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