INT252569

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.26
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Rpe)
Anatomy Link Frequency
retinas 1
face 1
Rpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 5 83.36 Quite High
imagery 30 77.56 Quite High
Inflammation 4 75.80 Quite High
cytokine 6 70.72 Quite High
beta blocker 2 21.20 Low Low
cva 7 17.08 Low Low
anesthesia 15 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 52 100.00 Very High Very High Very High
Injury 65 96.28 Very High Very High Very High
Lung Injury 4 84.08 Quite High
Cv Unclassified Under Development 4 83.36 Quite High
INFLAMMATION 6 75.80 Quite High
Edema 6 72.68 Quite High
Polyploidy 6 72.28 Quite High
Wound Healing 6 69.04 Quite High
Burns 42 67.60 Quite High
Age-related Macular Degeneration 6 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant increase in RPE cell proliferation in both peripheral and central retinas with increasing number of lesions (ANOVA; periphery F=8.56, p<0.001; center F=7.63, p<0.001; Figure 4).
Positive_regulation (increase) of RPE in retinas
1) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
We also show unexpectedly that small lesions induce RPE cell division globally.
Positive_regulation (induce) of RPE
2) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0.22 Pain Relevance 0
The RPE increase was significantly lower in the group where phase-1 CR was provided.
Positive_regulation (increase) of RPE
3) Confidence 0.37 Published 2010 Journal Heart Views : The Official Journal of the Gulf Heart Association Section Body Doc Link PMC3000912 Disease Relevance 0 Pain Relevance 0
Briefly, the purpose of using taurine in the diagnostic hypothesis during the initial symptom phases is protecting or reducing the risk of developing of lesions that lead RPE.
Positive_regulation (lead) of RPE associated with heart rate under development
4) Confidence 0.34 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2583976 Disease Relevance 0.90 Pain Relevance 0.08
Cells positive for the RPE cell marker Otx2 were present across the lesions site when tissue was viewed in section or en face (Figure 7A,B).
Positive_regulation (positive) of RPE in face
5) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
Unfortunately, such experiments have not been possible because the absorption of the laser that takes place when it hits the pigmented RPE is very different from that in the albino where no melanin is present to absorb the laser energy.
Positive_regulation (pigmented) of RPE
6) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0.14 Pain Relevance 0.04
Two experiments were performed investigating potential increases in RPE proliferation after lesioning.
Spec (investigating) Positive_regulation (increases) of RPE
7) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0.04
Irrespective of location, all lesions were associated with an upregulation of Ki67-positive cells in the RPE sheet.
Positive_regulation (upregulation) of RPE
8) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
On the apical surface of the cells, CD81 is associated with EBP50, and these proteins are upregulated on a similar time course as the RPE matures.
Positive_regulation (upregulated) of RPE
9) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0

General Comments

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