INT252582

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.62
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
lymph node 3
mast cell 1
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
interstitial cystitis 82 98.48 Very High Very High Very High
Inflammatory mediators 2 91.28 High High
Inflammation 66 90.24 High High
cytokine 28 79.72 Quite High
chemokine 24 77.52 Quite High
Bioavailability 1 71.12 Quite High
Lasting pain 2 53.24 Quite High
Inflammatory response 2 17.68 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 140 100.00 Very High Very High Very High
Interstitial Cystitis 82 98.48 Very High Very High Very High
INFLAMMATION 66 90.88 High High
Disease 37 74.28 Quite High
Oral Lichen Planus 2 58.80 Quite High
Infection 4 58.28 Quite High
Fever 2 57.56 Quite High
Cancer 4 56.76 Quite High
Hypertension 19 56.32 Quite High
Pain 2 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These clinical trends were consistent with CYP-induced cystitis in mice; CXCR3 ligands were elevated in mouse serum as well as urinary bladder and iliac lymph node lymphocytes.
Positive_regulation (elevated) of Gene_expression (consistent) of CYP in lymph node associated with cystitis
1) Confidence 0.12 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.22 Pain Relevance 0.42
In the present study, we noticed significant increases in mast cell numbers in the spleen, iliac lymph nodes, and urinary bladder after CYP induction and these increases were abrogated by anti-CXCL10 Ab treatment.
Positive_regulation (increases) of in mast cell Gene_expression (induction) of CYP in lymph nodes
2) Confidence 0.12 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.12 Pain Relevance 0.57
EET levels are dependent on the activity and expression of the CYP epoxygenases, which generate them and the enzyme soluble epoxide hydrolase (sEH) which converts the EETs to their corresponding dihydroxyeicosatrienoic acids (DHETs) [3].
Positive_regulation (dependent) of Gene_expression (expression) of CYP
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.29 Pain Relevance 0.15

General Comments

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