INT252588

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.61
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl11) extracellular region (Cxcl11)
Anatomy Link Frequency
lymph node 2
T cell 1
mast cell 1
Cxcl11 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 56 96.92 Very High Very High Very High
interstitial cystitis 164 90.64 High High
Inflammation 96 80.04 Quite High
chemokine 48 76.16 Quite High
Lasting pain 4 64.32 Quite High
Inflammatory response 4 28.76 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
pain pelvic 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 280 99.10 Very High Very High Very High
Interstitial Cystitis 164 90.64 High High
Disease 64 85.36 High High
INFLAMMATION 96 80.04 Quite High
Infection 8 69.36 Quite High
Fever 4 68.64 Quite High
Cancer 8 67.84 Quite High
Pain 4 64.32 Quite High
Pressure And Volume Under Development 4 21.76 Low Low
Overactive Bladder 4 15.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCL11 in T cell
1) Confidence 0.60 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.18 Pain Relevance 0.40
We demonstrate that CXCR3 as well as CXCL9, CXCL10 and CXCL11 mRNA were significantly expressed by urinary bladder lymphocytes, while CXCR3 and CXCL9 transcripts were significantly expressed by iliac lymph node leukocytes following CYP treatment.
Transcription (expressed) of CXCL11 in lymph node
2) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.55 Pain Relevance 0.35
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Transcription (expression) of CXCL11 in lymph node associated with cystitis
3) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.70 Pain Relevance 0.10
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCL11 in mast cell
4) Confidence 0.20 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.18 Pain Relevance 0.40

General Comments

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