INT252599

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10, Cxcr3) extracellular space (Cxcl10) extracellular region (Cxcl10)
plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
leukocytes 3
Cxcl10 (Mus musculus)
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 99.04 Very High Very High Very High
interstitial cystitis 41 69.36 Quite High
Inflammation 24 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 70 95.36 Very High Very High Very High
Interstitial Cystitis 41 69.36 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Colitis 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibody (Ab)-mediated inhibition of the most abundant serum CXCR3 ligand, CXCL10, in mice decreased the local production of CXCR3 ligands as well as Th1 cytokines expressed by local leukocytes, and lowered corresponding serum levels to reduce the severity of CYP-induced cystitis.
Negative_regulation (inhibition) of CXCL10 in leukocytes Negative_regulation (decreased) of Gene_expression (production) of CXCR3 in leukocytes associated with cystitis and cytokine
1) Confidence 0.45 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.49 Pain Relevance 0.29

General Comments

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