INT25263

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.35
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
nucleus accumbens 1
ileum 1
nasal 1
trachea 1
egg 1
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 24 100.00 Very High Very High Very High
depression 16 99.84 Very High Very High Very High
Nucleus accumbens 5 99.62 Very High Very High Very High
Clonidine 5 99.52 Very High Very High Very High
Dopamine 6 99.32 Very High Very High Very High
Hyperalgesia 4 99.20 Very High Very High Very High
withdrawal 10 99.08 Very High Very High Very High
Morphine 8 99.04 Very High Very High Very High
narcan 10 98.72 Very High Very High Very High
agonist 4 94.60 High High
Disease Link Frequency Relevance Heat
Depression 37 99.84 Very High Very High Very High
Skin Diseases 2 99.24 Very High Very High Very High
Hyperalgesia 4 99.20 Very High Very High Very High
Rhinitis 7 97.96 Very High Very High Very High
Cv Unclassified Under Development 2 95.36 Very High Very High Very High
Epilepsy 3 93.44 High High
Hyperkinesis 2 91.76 High High
Heart Rate Under Development 1 88.84 High High
Anaphylaxis 5 83.76 Quite High
Hypersensitivity 1 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of histamine H1 and H2 receptors attenuated the histamine-induced response.
Negative_regulation (Blockade) of histamine H1
1) Confidence 0.58 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575794 Disease Relevance 0 Pain Relevance 0.71
Also, pharmacological blockade of histamine H1 and H2 receptors decreased the naloxone-induced effect on water intake.
Negative_regulation (blockade) of histamine H1 associated with narcan
2) Confidence 0.58 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575794 Disease Relevance 0 Pain Relevance 0.72
Dopaminergic effects of histamine administration in the nucleus accumbens and the impact of H1-receptor blockade.
Negative_regulation (blockade) of H1-receptor in nucleus accumbens associated with nucleus accumbens
3) Confidence 0.41 Published 2001 Journal Neuropharmacology Section Title Doc Link 11249972 Disease Relevance 0 Pain Relevance 0.47
This multicenter, double-blind, placebo-controlled trial evaluated the efficacy and safety of levocabastine nasal spray, a potent and selective H1-receptor antagonist, in the control of histamine-mediated symptoms of seasonal allergic rhinitis.
Negative_regulation (antagonist) of H1-receptor in nasal associated with rhinitis and antagonist
4) Confidence 0.39 Published 1999 Journal Am J Rhinol Section Abstract Doc Link 10088031 Disease Relevance 0.41 Pain Relevance 0.05
Astemizole, a peripheral antagonist of H1 receptor, could not affect any withdrawal sign.
Negative_regulation (antagonist) of H1 receptor associated with antagonist and withdrawal
5) Confidence 0.39 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11526976 Disease Relevance 0.76 Pain Relevance 0.71
We have investigated the effects of mepyramine, an H1 receptor antagonist, and lysine acetylsalicylate, a cyclo-oxygenase inhibitor, on post-ischaemic hyperalgesia in rats.
Negative_regulation (inhibitor) of H1 receptor associated with hyperalgesia and antagonist
6) Confidence 0.37 Published 1986 Journal Pain Section Abstract Doc Link 3774353 Disease Relevance 0.41 Pain Relevance 0.42
The compound 48/80 response was partly inhibited by histamine H1 and H2 receptor blockade in the urinary bladder and in the duodenum, but not in the trachea, the oesophagus, the ureter and the paw skin.
Negative_regulation (blockade) of histamine H1 in trachea
7) Confidence 0.23 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6083460 Disease Relevance 0 Pain Relevance 0.31
In search of an improved treatment of pruritic dermatoses, we have studied azelastine, a novel H1-receptor antagonist, during a 2-week treatment period, using a double-blind, placebo-controlled design.
Negative_regulation (antagonist) of H1-receptor associated with skin diseases and antagonist
8) Confidence 0.17 Published 1998 Journal Allergy Section Abstract Doc Link 9534917 Disease Relevance 0.30 Pain Relevance 0.16
Diphenhydramine, an H1-receptor antagonist and cimetidine, an H2-receptor antagonist both significantly inhibited the histamine response but neither altered the response to egg albumin.
Negative_regulation (antagonist) of H1-receptor in egg associated with antagonist
9) Confidence 0.09 Published 1989 Journal Agents Actions Section Abstract Doc Link 2512772 Disease Relevance 0.60 Pain Relevance 0.28
Patients with depression show a decrease in H1 receptor binding, and this decrease is correlated with illness severity.34 Therefore, the modulation of histaminergic activity by quetiapine to induce sleep may be related to the reduction of depressive symptoms in these patients.
Negative_regulation (decrease) of H1 receptor associated with depression
10) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938299 Disease Relevance 0.69 Pain Relevance 0.23
No appreciable histamine H1-receptor activity was evident for either drug in experiments with guinea-pig ileum.
Neg (No) Negative_regulation (appreciable) of H1-receptor in ileum
11) Confidence 0.03 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7288630 Disease Relevance 0.18 Pain Relevance 0.56

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